Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. - Wikidata - awgldk - TriplyDB

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

http://www.wikidata.org/entity/Q34477787

about

The CD44+/CD24- phenotype is enriched in basal-like breast tumors Should individual PI3 kinase isoforms be targeted in cancer?PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha Comprehensive molecular portraits of human breast tumours Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives Cancer predisposition genes: molecular mechanisms and clinical impact on personalized cancer care: examples of Lynch and HBOC syndromes Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Genome-wide transcriptome profiling of homologous recombination DNA repair.Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.Triple-negative breast cancer and PTEN (phosphatase and tensin homologue) loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer.Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder.Novel therapeutic strategies in the treatment of triple-negative breast cancer.Phosphorylated p70S6K in noninvasive low-grade urothelial carcinoma of the bladder: correlation with tumor recurrence.Estrogen receptor-negative breast cancer: new insights into subclassification and targeting Genomic instability in breast cancer: pathogenesis and clinical implications PIK3CA mutations in in situ and invasive breast carcinomas.Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line Oncogenes and tumor suppressor genes Breast cancer susceptibility: current knowledge and implications for genetic counselling Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.Evolutionary pathways in BRCA1-associated breast tumors.Treatment options for patients with triple-negative breast cancer Genetically engineered mouse models of PI3K signaling in breast cancer.Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.Characteristics of triple-negative breast cancer Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair Micro-scale genomic DNA copy number aberrations as another means of mutagenesis in breast cancer.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

http://www.wikidata.org/entity/Q34477787

description

2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Recurrent gross mutations of t ...... ers with deficient DSB repair.

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Nature Genetics

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Ake Borg

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Camilla Persson

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Göran Jönsson

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Kristina Lövgren

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Lorenzo Memeo

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Maira M Pires

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P2860

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data.

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

The consensus coding sequences of human breast and colorectal cancers

Molecular portraits of human breast tumours

Repeated observation of breast tumor subtypes in independent gene expression data sets

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

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10.1038/NG.2007.39

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1

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Johan Vallon-Christersson

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