Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.
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The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformationRelaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathwaysStructure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 AgonistSolution structure of a conformationally restricted fully active derivative of the human relaxin-like factorIn vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependencyOrigin of INSL3-mediated testicular descent in therian mammalsDevelopment of a selective agonist for relaxin family peptide receptor 3.A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization.Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)C-terminus of the B-chain of relaxin-3 is important for receptor activityInternational Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?Chemical synthesis of peptides within the insulin superfamily.Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3.Relaxin family peptides: structure-activity relationship studies.Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue.Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies.The mode of interaction of the relaxin-like factor (RLF) with the leucine-rich repeat G protein-activated receptor 8.Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.Orthosteric, Allosteric and Biased Signalling at the Relaxin-3 Receptor RXFP3.Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.The relaxin peptide family - potential future hope for neuroprotective therapy? A short review.
P2860
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P2860
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Solution structure and novel i ...... pecificity of human relaxin-3.
@ast
Solution structure and novel i ...... pecificity of human relaxin-3.
@en
Solution structure and novel i ...... pecificity of human relaxin-3.
@nl
type
label
Solution structure and novel i ...... pecificity of human relaxin-3.
@ast
Solution structure and novel i ...... pecificity of human relaxin-3.
@en
Solution structure and novel i ...... pecificity of human relaxin-3.
@nl
prefLabel
Solution structure and novel i ...... pecificity of human relaxin-3.
@ast
Solution structure and novel i ...... pecificity of human relaxin-3.
@en
Solution structure and novel i ...... pecificity of human relaxin-3.
@nl
P2860
P50
P356
P1476
Solution structure and novel i ...... specificity of human relaxin-3
@en
P2093
Geoffrey W Tregear
P2860
P304
P356
10.1074/JBC.M511210200
P407
P577
2005-12-19T00:00:00Z