Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle - Wikidata - awgldk - TriplyDB

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

http://www.wikidata.org/entity/Q34478731

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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue.PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.Exercise-mimetic AICAR transiently benefits brain function.Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Multi-Scale Continuum Modeling of Biological Processes: From Molecular Electro-Diffusion to Sub-Cellular Signaling Transduction Structural determinants of muscle thin filament cooperativity.2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy.AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility.Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy.Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.Contractility and kinetics of human fetal and human adult skeletal muscle.Identification and analysis of a key long non-coding RNAs (lncRNAs)-associated module reveal functional lncRNAs in cardiac hypertrophy.An analysis of deformation-dependent electromechanical coupling in the mouse heart.Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.Contractile properties of developing human fetal cardiac muscle.Low-density lipoprotein receptor is a calcium/magnesium sensor - role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome

P2860

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P2860

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

http://www.wikidata.org/entity/Q34478731

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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J.YJMCC.2010.10.025

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Journal of Molecular and Cellular Cardiology

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Calcium binding kinetics of tr ...... ion kinetics in cardiac muscle

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Chiara Tesi

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Corrado Poggesi

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Jonathan T McMichael

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Kareen L Kreutziger

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Michael Regnier

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Nicoletta Piroddi

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P2860

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C

Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle.

Influence of length on force and activation-dependent changes in troponin c structure in skinned cardiac and fast skeletal muscle.

Kinetic studies of calcium binding to the regulatory site of troponin C from cardiac muscle

Regulation of contraction in striated muscle

Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction.

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