Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons - Wikidata - awgldk - TriplyDB

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

http://www.wikidata.org/entity/Q34478763

about

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor Mammalian phospholipase D physiological and pathological roles Trafficking regulation of proteins in Alzheimer's disease Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala APP processing in Alzheimer's disease Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1 PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.Alzheimer's disease risk genes and mechanisms of disease pathogenesis Pathological and physiological functions of presenilins.Linking lipids to Alzheimer's disease: cholesterol and beyond.Phospholipase D in brain function and Alzheimer's disease.A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling.Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish.Presenilin: RIP and beyond.Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort.Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.Chemical modulation of glycerolipid signaling and metabolic pathways.Lipidomics of Alzheimer's disease.PLD3 in Alzheimer's disease.Alzheimer's disease genetics: from the bench to the clinic.Alzheimer's Disease Risk Genes and Lipid Regulators.The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis.Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway.Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1 Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease.Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures.

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P2860

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

http://www.wikidata.org/entity/Q34478763

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons

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Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons

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Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons

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Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons

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David A Foster

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Dennis Shields

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Dongming Cai

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Fred S Gorelick

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Huaxi Xu

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Hui Zheng

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Minghao Zhong

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Runsheng Wang

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Sangram S Sisodia

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William J Netzer

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P2860

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Mechanisms of intracellular protein transport

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

Phospholipase D

Role for phospholipase D in receptor-mediated endocytosis

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

Disease models provide insights into post-golgi protein trafficking, localization and processing.

Cellular and molecular basis of beta-amyloid precursor protein metabolism.

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16449385

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Alzheimer's disease

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1413666

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