Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons
about
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's diseasePresenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factorMammalian phospholipase D physiological and pathological rolesTrafficking regulation of proteins in Alzheimer's diseaseDopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdalaAPP processing in Alzheimer's diseaseSmall molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophyAmyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.Alzheimer's disease risk genes and mechanisms of disease pathogenesisPathological and physiological functions of presenilins.Linking lipids to Alzheimer's disease: cholesterol and beyond.Phospholipase D in brain function and Alzheimer's disease.A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial DysfunctionSorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling.Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsPhospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish.Presenilin: RIP and beyond.Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort.Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.Chemical modulation of glycerolipid signaling and metabolic pathways.Lipidomics of Alzheimer's disease.PLD3 in Alzheimer's disease.Alzheimer's disease genetics: from the bench to the clinic.Alzheimer's Disease Risk Genes and Lipid Regulators.The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis.Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway.Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease.Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures.
P2860
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P2860
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@ast
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@en
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@nl
type
label
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@ast
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@en
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@nl
prefLabel
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@ast
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@en
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@nl
P2093
P2860
P356
P1476
Phospholipase D1 corrects impa ...... ed presenilin-1 mutant neurons
@en
P2093
David A Foster
Dennis Shields
Dongming Cai
Fred S Gorelick
Minghao Zhong
Runsheng Wang
Sangram S Sisodia
William J Netzer
P2860
P304
P356
10.1073/PNAS.0510710103
P407
P577
2006-01-31T00:00:00Z