about
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) ProdrugsA new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding.Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells.DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing.Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity.The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association.Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNAPlatinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cellsAxial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics.Rational design of [Co(acacen)L2]+ inhibitors of protein functionInvestigations of the binding of [Pt2(DTBPA)Cl2](II) and [Pt2(TPXA)Cl2](II) to DNA via various cross-linking modes.Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrestSynthetic methods for the preparation of platinum anticancer complexes.Competitive formation of both long-range 5'-5' and short-range antiparallel 3'-3' DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex.Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs.A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds.Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp.Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets.Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum.Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.Differentiation and distributions of DNA/cisplatin crosslinks by liquid chromatography-electrospray ionization-infrared multiphoton dissociation mass spectrometryGeometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity.Comparison of MS/MS methods for characterization of DNA/cisplatin adducts.Translesion DNA synthesis across double-base lesions derived from cross-links of an antitumor trinuclear platinum compound: primer extension, conformational and thermodynamic studies.Analogues of Cis- and Transplatin with a Rich Solution Chemistry: cis-[PtCl2 (NH3 )(1-MeC-N3)] and trans-[PtI2 (NH3 )(1-MeC-N3)].Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex.Biological evaluation of dimethylpyridine-platinum complexes with potent antiproliferative activity.Osmium-Nitrosyl Oxalato-Bridged Lanthanide-Centered Pentanuclear Complexes - Synthesis, Crystal Structures and Magnetic PropertiesPlatinum and Palladium Polyamine Complexes as Anticancer Agents: The Structural Factor
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Excursions in polynuclear platinum DNA binding.
@ast
Excursions in polynuclear platinum DNA binding.
@en
Excursions in polynuclear platinum DNA binding.
@nl
type
label
Excursions in polynuclear platinum DNA binding.
@ast
Excursions in polynuclear platinum DNA binding.
@en
Excursions in polynuclear platinum DNA binding.
@nl
prefLabel
Excursions in polynuclear platinum DNA binding.
@ast
Excursions in polynuclear platinum DNA binding.
@en
Excursions in polynuclear platinum DNA binding.
@nl
P2860
P356
P1476
Excursions in polynuclear platinum DNA binding.
@en
P2093
John B Mangrum
Nicholas P Farrell
P2860
P304
P356
10.1039/C0CC01254H
P407
P577
2010-08-09T00:00:00Z