High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells. - Wikidata - awgldk - TriplyDB

High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.

High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.

http://www.wikidata.org/entity/Q34481639

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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care EMT, CTCs and CSCs in tumor relapse and drug-resistance Chemotherapy targeting cancer stem cells Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells A novel anticancer agent SNG1153 inhibits growth of lung cancer stem/progenitor cells Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy.Latest progress in tyrosine kinase inhibitors Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.ABC transporters in CSCs membranes as a novel target for treating tumor relapse.Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.Repurposing Drugs in Oncology (ReDO)-itraconazole as an anti-cancer agent.Combining targeted drugs to overcome and prevent resistance of solid cancers with some stem-like cell features.Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells.Getting to the source: selective drug targeting of cancer stem cells.Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors.Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs.Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.Emerging targets for glioblastoma stem cell therapy Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures.Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels.Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells.PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide.High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells.Glioma stem cells: turpis omen in nomen? (The evil in the name?).Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling.Toward precision medicine in glioblastoma: the promise and the challenges.Existing drugs and their application in drug discovery targeting cancer stem cells.Anti-Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres.Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing.Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.Cytotoxic constituents of Abutilon indicum leaves against U87MG human glioblastoma cells.

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High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.

http://www.wikidata.org/entity/Q34481639

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2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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High-throughput chemical scree ...... human glioblastoma stem cells.

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Greg Foltz

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Jae-Geun Yoon

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Liping Chen

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Loic Deleyrolle

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Timothy J Martins

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P2860

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.

miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomas

Targeting glioma stem cells: a novel framework for brain tumors

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals

Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma

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