The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA.
about
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix proteinThe bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreasThe bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identityEvolutionary silencing of the human elastase I gene (ELA1)The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisRNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factorsThe DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse developmentEarly pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complexGeneration and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.The subunit structure of Saccharomyces cerevisiae transcription factor IIIC probed with a novel photocrosslinking reagent.Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf.A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture.Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase.Cooperation between elements of an organ-specific transcriptional enhancer in animalsA single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut.Transactivation of pancreas-specific gene sequences in somatic cell hybridsExocrine pancreas transcription factor 1 binds to a bipartite enhancer element and activates transcription of acinar genes.PASTAA: identifying transcription factors associated with sets of co-regulated genes.On the origin of the beta cell.MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.The role of PTF1-P48 in pancreatic acinar gene expression.Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.The bHLH domain of Mistl is sufficient to activate gene transcription.Compilation of vertebrate-encoded transcription factorsIdentification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene.Integration of tetracycline regulation into a cell-specific transcriptional enhancer.Identification of cis- and trans-acting factors regulating the expression of rat salivary-specific RP4 gene.A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression.Pancreas transcription factor 1alpha expression is regulated in pancreatitis.Mechanistic insights into the activity of Ptf1-p48 (pancreas transcription factor 1a): probing the interactions levels of Ptf1-p48 with E2A-E47 (transcription factor E2-alpha) and ID3 (inhibitor of DNA binding 3).Pancreatic adenocarcinoma, chronic pancreatitis, and MODY-8 diabetes: is bile salt-dependent lipase (or carboxyl ester lipase) at the crossroads of pancreatic pathologies?
P2860
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P2860
The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA.
description
1989 nî lūn-bûn
@nan
1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
The cell-specific transcriptio ...... ts that interact with the DNA.
@ast
The cell-specific transcriptio ...... ts that interact with the DNA.
@en
The cell-specific transcriptio ...... ts that interact with the DNA.
@nl
type
label
The cell-specific transcriptio ...... ts that interact with the DNA.
@ast
The cell-specific transcriptio ...... ts that interact with the DNA.
@en
The cell-specific transcriptio ...... ts that interact with the DNA.
@nl
prefLabel
The cell-specific transcriptio ...... ts that interact with the DNA.
@ast
The cell-specific transcriptio ...... ts that interact with the DNA.
@en
The cell-specific transcriptio ...... ts that interact with the DNA.
@nl
P2093
P356
P1433
P1476
The cell-specific transcriptio ...... ts that interact with the DNA.
@en
P2093
Hagenbüchle O
Wellauer PK
P304
P356
10.1101/GAD.3.10.1613
P577
1989-10-01T00:00:00Z