Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity. - Wikidata - awgldk - TriplyDB

Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.

Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.

http://www.wikidata.org/entity/Q34490557

about

Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.ATP2C1 gene mutations in Hailey-Hailey disease and possible roles of SPCA1 isoforms in membrane trafficking "Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies"Manganese homeostasis in the nervous system Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity Exposure, epidemiology, and mechanism of the environmental toxicant manganese.Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin.Golgi localized barley MTP8 proteins facilitate Mn transport.Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.A Conserved Structural Motif Mediates Retrograde Trafficking of Shiga Toxin Types 1 and 2 A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIA Shiga toxin-binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms.Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes Golgi phosphoprotein 4 (GPP130) is a sensitive and selective cellular target of manganese exposure.The role of the Golgi-resident SPCA Ca²⁺/Mn²⁺ pump in ionic homeostasis and neural function.Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter.Engineering an effective Mn-binding MRI reporter protein by subcellular targeting Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity.Influence of iron metabolism on manganese transport and toxicity.Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis.Manganese-induced turnover of TMEM165.Syndesome Therapeutics for Enhancing Diabetic Wound Healing Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis.Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity.Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin.Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.Inherited Disorders of Manganese Metabolism.Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking.Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.

P2860

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P2860

Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.

http://www.wikidata.org/entity/Q34490557

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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prefLabel

Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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Identification of a gain-of-fu ...... and protects against toxicity.

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PNAS.1013642108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Identification of a gain-of-fu ...... and protects against toxicity

@en

P2093

Adam D Linstedt

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P2860

Functional expression in yeast of the human secretory pathway Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease

Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)

COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation

Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein

Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses

Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis

MODBASE: a database of annotated comparative protein structure models and associated resources.

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

Structural changes in the calcium pump accompanying the dissociation of calcium

Manganese selectivity of pmr1, the yeast secretory pathway ion pump, is defined by residue gln783 in transmembrane segment 6. Residue Asp778 is essential for cation transport.

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10.1073/PNAS.1013642108

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2

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Somshuvra Mukhopadhyay

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