The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.

The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.

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http://www.wikidata.org/entity/Q34490663

Q34490663

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A role for the androgen metabolite, 5alpha androstane 3beta, 17beta diol (3β-diol) in the regulation of the hypothalamo-pituitary-adrenal axis Comparison of the effects of estradiol and progesterone on serotonergic function Roles for oestrogen receptor β in adult brain function The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation Genetic, epigenetic and environmental impact on sex differences in social behavior.Oxytocin and Estrogen Receptor β in the Brain: An Overview Sex differences and stress across the lifespan Estrogen receptors and the regulation of neural stress responses Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration Selective contributions of the medial preoptic nucleus to testosterone-dependant regulation of the paraventricular nucleus of the hypothalamus and the HPA axis 17β-estradiol differentially regulates stress circuitry activity in healthy and depressed women.Dysregulation of neonatal hippocampal cell genesis in the androgen insensitive Tfm rat Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model.Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.Chronic exposure to a predator or its scent does not inhibit male-male competition in male mice lacking brain serotonin.Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress.Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines.Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei.Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.Metabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study Sex differences in stress response circuitry activation dependent on female hormonal cycle Effects of 5α-dihydrotestosterone and 17β-estradiol on the mouse ovarian follicle development and oocyte maturation.Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study Estrogen receptor beta activation prevents glucocorticoid receptor-dependent effects of the central nucleus of the amygdala on behavior and neuroendocrine function Relative adrenal insufficiency in mice deficient in 5α-reductase 1 Oestrogen receptor beta is involved in the actions of oestrogens in the brain for affective behaviour, but not trophic effects in peripheral tissues.Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.Modification of female and male social behaviors in estrogen receptor beta knockout mice by neonatal maternal separation.17β-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence.Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats.Prenatal influence of an androgen agonist and antagonist on the differentiation of the ovine sexually dimorphic nucleus in male and female lamb fetuses.Androgenic influence on serotonergic activation of the HPA stress axis Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men.5α-Reduced neurosteroids sex-dependently reverse central prenatal programming of neuroendocrine stress responses in rats.Androgen receptors in the posterior bed nucleus of the stria terminalis increase neuropeptide expression and the stress-induced activation of the paraventricular nucleus of the hypothalamus.Secretagogue type, sex-steroid milieu, and abdominal visceral adiposity individually determine secretagogue-stimulated cortisol secretion Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness.

P2860

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P2860

The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.

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http://www.wikidata.org/entity/Q34490663

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