about
Undercover: gene control by metabolites and metabolic enzymesSIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferationSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsNuclear DNA damage signalling to mitochondria in ageingInsights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer.Is SIRT6 Activity Neuroprotective and How Does It Differ from SIRT1 in This Regard?Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent MechanismMetabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape.Novel investigational drugs mimicking exercise for the treatment of cachexia.Targeting metabolic pathways for head and neck cancers therapeutics.Development of substrate-derived mechanistic sirtuin inhibitors with potential anti-cancer activity.Emerging roles for SIRT5 in metabolism and cancer.The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.Metabolic interactions with cancer epigenetics.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.SIRT6: Novel Mechanisms and Links to Aging and Disease.Melatonin and sirtuins: A "not-so unexpected" relationship.The seven faces of SIRT7.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Sirtuins Expression and Their Role in Retinal Diseases.A chemical probe toolbox for dissecting the cancer epigenome.Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast.The Role of Reactive Oxygen Species and Autophagy in Periodontitis and Their Potential Linkage.Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.Wnt signalling meets epigenetics.SIRT7 clears the way for DNA repair.As"SIRT"ing the role of an epigenetic modifier in hematopoietic stem cell homeostasis.Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.Epidermal SIRT1 regulates inflammation, cell migration, and wound healingThe Glycolytic Switch in Tumors: How Many Players Are Involved?The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.DNA damage and neurodegeneration: the unusual suspect.Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
The multifaceted functions of sirtuins in cancer.
@ast
The multifaceted functions of sirtuins in cancer.
@en
The multifaceted functions of sirtuins in cancer.
@nl
type
label
The multifaceted functions of sirtuins in cancer.
@ast
The multifaceted functions of sirtuins in cancer.
@en
The multifaceted functions of sirtuins in cancer.
@nl
prefLabel
The multifaceted functions of sirtuins in cancer.
@ast
The multifaceted functions of sirtuins in cancer.
@en
The multifaceted functions of sirtuins in cancer.
@nl
P356
P1476
The multifaceted functions of sirtuins in cancer.
@en
P2093
Angeliki Chalkiadaki
Leonard Guarente
P2888
P304
P356
10.1038/NRC3985
P407
P577
2015-09-18T00:00:00Z
P6179
1038813311