Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.
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Arginine Metabolism in Bacterial Pathogenesis and Cancer TherapyAmino acid deprivation using enzymes as a targeted therapy for cancer and viral infectionsArgininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy.Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy.Extensive decoupling of metabolic genes in cancer.The therapy of gefitinib towards breast cancer partially through reversing breast cancer biomarker arginine.Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity.A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availabilityReduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance.A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor.Drug-induced amino acid deprivation as strategy for cancer therapy.Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug.Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase.Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer CellsHuman mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers.Arginine-Dual roles as an onconutrient and immunonutrient.Mitochondria are the powerhouses of immunity.Metabolic reprogramming in clear cell renal cell carcinoma.Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer.Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells.Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway.Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer.Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
P2860
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P2860
Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.
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2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Arginine starvation impairs mi ...... deficient breast cancer cells.
@ast
Arginine starvation impairs mi ...... deficient breast cancer cells.
@en
Arginine starvation impairs mi ...... deficient breast cancer cells.
@nl
type
label
Arginine starvation impairs mi ...... deficient breast cancer cells.
@ast
Arginine starvation impairs mi ...... deficient breast cancer cells.
@en
Arginine starvation impairs mi ...... deficient breast cancer cells.
@nl
prefLabel
Arginine starvation impairs mi ...... deficient breast cancer cells.
@ast
Arginine starvation impairs mi ...... deficient breast cancer cells.
@en
Arginine starvation impairs mi ...... deficient breast cancer cells.
@nl
P2093
P2860
P50
P1433
P1476
Arginine starvation impairs mi ...... -deficient breast cancer cells
@en
P2093
Cheng-Ying Chu
David K Ann
Fuming Qiu
Hang Zhang
Hsing-Jien Kung
Jinghong Xu
Li-Jiuan Shen
Shikha Gaur
P2860
P356
10.1126/SCISIGNAL.2004761
P577
2014-04-01T00:00:00Z