A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours.
about
The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challengesMaximising the potential of AKT inhibitors as anti-cancer treatmentsMolecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway BlockadeRecent advances in the pathobiology and management of Kasabach-Merritt phenomenon.A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumorsExpression of phospho-mTOR kinase is abundant in colorectal cancer and associated with left-sided tumor localization.Potential impact of mTOR inhibitors on cervical squamous cell carcinoma: A systematic review.Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric cancer cells.Emerging therapeutic targets in metastatic progression: A focus on breast cancer.Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest.Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives.Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination StudiesIGF-binding protein 2 is a candidate target of therapeutic potential in cancer.Hormone receptor positive, HER2 negative metastatic breast cancer: Future treatment landscape.Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature.High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas.TMED2 promotes epithelial ovarian cancer growth.Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment.AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity.Dose-finding designs for trials of molecularly targeted agents and immunotherapies.Akt2/ZEB2 may be a biomarker for exfoliant cells in ascitic fluid in advanced grades of serous ovarian carcinoma.
P2860
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P2860
A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours.
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@ast
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@en
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@nl
type
label
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@ast
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@en
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@nl
prefLabel
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@ast
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@en
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@nl
P2093
P2860
P921
P356
P1476
A parallel-arm phase I trial o ...... s with advanced solid tumours.
@en
P2093
A Gunchenko
D M Sullivan
J Edenfield
J Stephenson
K Almhanna
P2860
P2888
P304
P356
10.1038/BJC.2014.497
P407
P577
2014-10-07T00:00:00Z
P5875
P6179
1021555113