Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer - Wikidata - awgldk - TriplyDB

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

http://www.wikidata.org/entity/Q34501536

about

NTRK gene fusions as novel targets of cancer therapy across multiple tumour types HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells.Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer Molecular Testing for Gastrointestinal Cancer.Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience.Novel therapeutics in metastatic colorectal cancer: molecular insights and pharmacogenomic implications.Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model.Causes and consequences of nuclear envelope alterations in tumour progression.Emerging tyrosine kinase inhibitors for the treatment of metastatic colorectal cancer.Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient.Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).Infantile NTRK-associated Mesenchymal Tumors.Identification of NTRK fusions in pediatric mesenchymal tumors.Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.Colorectal cancer genomics and designing rational trials.The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.Navigating Systemic Therapy in Advanced Thyroid Carcinoma: From Standard of Care to Personalized Therapy and Beyond The Winding Roadmap of Biomarkers toward Clinic: Lessons from Predictors of Resistance to Anti-EGFRs in Metastatic Colorectal Cancer PATRI, a Genomics Data Integration Tool for Biomarker Discovery

P2860

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P2860

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

http://www.wikidata.org/entity/Q34501536

description

2015 nî lūn-bûn

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2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2015 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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P1433

Journal of the National Cancer Institute

P1476

Sensitivity to Entrectinib Ass ...... n Metastatic Colorectal Cancer

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P2093

Alessio Somaschini

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Antonella Isacchi

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Antonella Leone

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Arturo Galvani

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Cristina Davite

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David Luo

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Elena Ardini

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Erica Bonazzina

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Giovanna Marrapese

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Jonathan Lim

http://www.w3.org/2001/XMLSchema#string

P2860

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.

The landscape of kinase fusions in cancer

Tyrosine kinase gene rearrangements in epithelial malignancies.

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

A conserved splicing mechanism of the LMNA gene controls premature aging.

Anchored multiplex PCR for targeted next-generation sequencing.

P31

scholarly article

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10.1093/JNCI/DJV306

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P433

1

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108

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Andrea Sartore-Bianchi

Silvio Marco Veronese

Angelo Vanzulli

Alberto Bardelli

Salvatore Siena

Emanuele Valtorta

P577

2015-11-12T00:00:00Z

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P5875

283748148

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26563355

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colorectal cancer

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4712682

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