The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
about
Trace amine-associated receptors and their ligandsThe tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptorsA microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptorCrystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptorDopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulationsStructure modeling of all identified G protein-coupled receptors in the human genomeStructure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistGeneric GPCR residue numbers - aligning topology maps while minding the gapsTrace amine-associated receptors: ligands, neural circuits, and behaviorsReceptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivoMining significant substructure pairs for interpreting polypharmacology in drug-target networkModeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugsA novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous systemHomology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluationDeterminants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug designEvaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A.The importance of odorant conformation to the binding and activation of a representative olfactory receptorStructure-function of the G protein-coupled receptor superfamily.Ligand discovery from a dopamine D3 receptor homology model and crystal structureResidues in the first extracellular loop of a G protein-coupled receptor play a role in signal transduction.GPCR antitarget modeling: pharmacophore models for biogenic amine binding GPCRs to avoid GPCR-mediated side effects.Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methodsStructure prediction of the second extracellular loop in G-protein-coupled receptorsHow a small change in retinal leads to G-protein activation: initial events suggested by molecular dynamics calculations.Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.The allosteric vestibule of a seven transmembrane helical receptor controls G-protein couplingGPCRRD: G protein-coupled receptor spatial restraint database for 3D structure modeling and function annotationProbing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors.GPCR-I-TASSER: A Hybrid Approach to G Protein-Coupled Receptor Structure Modeling and the Application to the Human Genome.Effect of prazosin on diabetic nephropathy patients with positive α1-adrenergic receptor autoantibodies and refractory hypertension.The activity of prolactin releasing peptide correlates with its helicity.Development of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.Homology modeling of opioid receptor-ligand complexes using experimental constraintsWhat can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?G protein-coupled receptor rhodopsin.Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.
P2860
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P2860
The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The binding site of aminergic ...... and second extracellular loop.
@ast
The binding site of aminergic ...... and second extracellular loop.
@en
The binding site of aminergic ...... and second extracellular loop.
@nl
type
label
The binding site of aminergic ...... and second extracellular loop.
@ast
The binding site of aminergic ...... and second extracellular loop.
@en
The binding site of aminergic ...... and second extracellular loop.
@nl
prefLabel
The binding site of aminergic ...... and second extracellular loop.
@ast
The binding site of aminergic ...... and second extracellular loop.
@en
The binding site of aminergic ...... and second extracellular loop.
@nl
P1476
The binding site of aminergic ...... and second extracellular loop.
@en
P2093
Jonathan A Javitch
P304
P356
10.1146/ANNUREV.PHARMTOX.42.091101.144224
P577
2002-01-01T00:00:00Z