A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate.
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SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcriptionTyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphataseDistinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesDemonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitroPhysical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fynCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptorCD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transductionIdentification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cellsMolecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytesRole of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signaMolecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells.Identification of amino acids at the junction of exons 3 and 7 that are used for the generation of glycosylation-related human CD45RO and CD45RO-like antigen specificities.Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell cloneProtein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases.The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulationCD45-associated protein promotes the response of primary CD4 T cells to low-potency T-cell receptor (TCR) stimulation and facilitates CD45 association with CD3/TCR and lck.Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cellsSpecific CD45 isoforms differentially regulate T cell receptor signalingCD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line.Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.Evidence for an association of CD45 with 32,000-33,000 MW phosphoproteins on murine T and B lymphocytes.Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).The role of CD45 and CD45-associated molecules in T cell activation.Reconstitution of interactions between protein-tyrosine phosphatase CD45 and tyrosine-protein kinase p56(lck) in nonlymphoid cells.Identification of a novel dimeric phosphoprotein (PP29/30) associated with signaling receptors in human T lymphocytes and natural killer cells.Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase.Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions.Recruitment of Activated p56lckon Endosomes of CD2-triggered T Cells, Colocalization with ZAP-70Interactions of CD45-associated Protein with the Antigen Receptor Signaling Machinery in T-lymphocytes
P2860
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P2860
A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate.
description
1991 nî lūn-bûn
@nan
1991 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
A functional complex is formed ...... , a possible common substrate.
@ast
A functional complex is formed ...... , a possible common substrate.
@en
A functional complex is formed ...... , a possible common substrate.
@nl
type
label
A functional complex is formed ...... , a possible common substrate.
@ast
A functional complex is formed ...... , a possible common substrate.
@en
A functional complex is formed ...... , a possible common substrate.
@nl
prefLabel
A functional complex is formed ...... , a possible common substrate.
@ast
A functional complex is formed ...... , a possible common substrate.
@en
A functional complex is formed ...... , a possible common substrate.
@nl
P2093
P356
P1476
A functional complex is formed ...... , a possible common substrate.
@en
P2093
P304
P356
10.1002/EJI.1830211025
P407
P577
1991-10-01T00:00:00Z