Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.
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Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesisMolecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes MellitusThe Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPPAmylin at the interface between metabolic and neurodegenerative disordersHsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes TreatmentBridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive PotentialType 2 diabetes and Alzheimer's disease: from common pathologies to potential new therapeutics.Human islet xenotransplantation in rodents: A literature review of experimental model trends.Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis.Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.Amyloid in the islets of Langerhans: thoughts and some historical aspects.Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.Inhibition of glycosaminoglycan-mediated amyloid formation by islet amyloid polypeptide and proIAPP processing intermediates.Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation.The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans.Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity.Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.Further evidence for amyloid deposition in clinical pancreatic islet grafts.A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions.Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state.The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes.Extensive amyloid formation in transplanted microencapsulated mouse and human islets.BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells.Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity
P2860
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P2860
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Intracellular amyloid-like dep ...... and transplanted human islets.
@ast
Intracellular amyloid-like dep ...... and transplanted human islets.
@en
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide
@nl
type
label
Intracellular amyloid-like dep ...... and transplanted human islets.
@ast
Intracellular amyloid-like dep ...... and transplanted human islets.
@en
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide
@nl
prefLabel
Intracellular amyloid-like dep ...... and transplanted human islets.
@ast
Intracellular amyloid-like dep ...... and transplanted human islets.
@en
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide
@nl
P2093
P1433
P1476
Intracellular amyloid-like dep ...... and transplanted human islets
@en
P2093
A Andersson
G T Westermark
P Westermark
P2860
P2888
P304
P356
10.1007/S00125-006-0206-7
P577
2006-03-29T00:00:00Z
P5875
P6179
1017397078