AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerResistant mechanisms to BRAF inhibitors in melanomaOncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer CellsMEK and PI3K inhibition in solid tumors: rationale and evidence to datePI3K and AKT: Unfaithful Partners in CancerTargeting Breast Cancer MetastasisCancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasionAdaptive resistance to targeted therapies in cancerTen things you should know about protein kinases: IUPHAR Review 14Targeting the mTOR signaling pathway in neuroendocrine tumorsThe dynamic nature of the kinomePhosphatidylinositol 3-kinase and antiestrogen resistance in breast cancerBeyond BRAF: where next for melanoma therapy?An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or NeuregulinDiscovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitorsPIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activationESR1 ligand-binding domain mutations in hormone-resistant breast cancer.Molecular Pathways: AXL, a Membrane Receptor Mediator of Resistance to TherapyMaximising the potential of AKT inhibitors as anti-cancer treatmentsThe Complexity of Targeting PI3K-Akt-mTOR Signalling in Human Acute Myeloid Leukaemia: The Importance of Leukemic Cell Heterogeneity, Neighbouring Mesenchymal Stem Cells and Immunocompetent CellsThe Antibiotic Drug Tigecycline: A Focus on its Promising Anticancer PropertiesTargeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?The phosphoinositide 3-kinase pathway and therapy resistance in cancerMapping the Pathways of Resistance to Targeted TherapiesPTEN is a protein tyrosine phosphatase for IRS1Mechanisms of action of therapeutic antibodies for cancerSystematic identification of combinatorial drivers and targets in cancer cell linesPerturbation biology: inferring signaling networks in cellular systemsDiscovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitorIdentifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discoveryEndothelial Cell mTOR Complex-2 Regulates Sprouting AngiogenesisSystems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1BPten loss promotes MAPK pathway dependency in HER2/neu breast carcinomasCellular effects of HER3-specific affibody moleculesPI3K and cancer: lessons, challenges and opportunitiesNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks.
P2860
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P2860
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
AKT inhibition relieves feedba ...... kinase expression and activity
@ast
AKT inhibition relieves feedba ...... kinase expression and activity
@en
AKT inhibition relieves feedba ...... kinase expression and activity
@nl
type
label
AKT inhibition relieves feedba ...... kinase expression and activity
@ast
AKT inhibition relieves feedba ...... kinase expression and activity
@en
AKT inhibition relieves feedba ...... kinase expression and activity
@nl
prefLabel
AKT inhibition relieves feedba ...... kinase expression and activity
@ast
AKT inhibition relieves feedba ...... kinase expression and activity
@en
AKT inhibition relieves feedba ...... kinase expression and activity
@nl
P2093
P2860
P1433
P1476
AKT inhibition relieves feedba ...... kinase expression and activity
@en
P2093
Ayana Sawai
Maurizio Scaltriti
Neal Rosen
Olivera Grbovic-Huezo
Pradip K Majumder
Sarat Chandarlapaty
Vanessa Rodrik-Outmezguine
P2860
P356
10.1016/J.CCR.2010.10.031
P577
2011-01-06T00:00:00Z