Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
about
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeMO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADHeat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityNonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and MouseMolecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancerTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesMultifocal epithelial tumors and field cancerization: stroma as a primary determinantStem cell dynamics and pretumor progression in the intestinal tractLKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domainAberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the cryptThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionHaploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouseLKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis.Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladderHereditary hamartomatous polyposis syndromes: understanding the disease risks as children reach adulthood.Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposisInduction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in miceMouse models of inherited cancer syndromesLKB1, the multitasking tumour suppressor kinaseA mouse model of human oral-esophageal cancer.LKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersA specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNADisabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null backgroundScreening for microsatellite instability target genes in colorectal cancers.The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis.Cancer risks in LKB1 germline mutation carriers.Three novel mutations of STK11 gene in Chinese patients with Peutz-Jeghers syndrome.Intact LKB1 activity is required for survival of dormant ovarian cancer spheroidsLkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brainLKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell linesPeutz-Jeghers syndrome with small intestinal malignancy and cervical carcinoma
P2860
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P2860
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@ast
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@en
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@nl
type
label
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@ast
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@en
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@nl
prefLabel
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@ast
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@en
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@nl
P2093
P1433
P1476
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
@en
P2093
Hiroyuki Miyoshi
Makoto M Taketo
Masanobu Oshima
Masayuki Nakau
Michael F Seldin
Tomo-o Ishikawa
P304
P407
P577
2002-04-01T00:00:00Z