Molecular genetics of human leukemias: new insights into therapy.
about
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcriptionThe genetic basis of early T-cell precursor acute lymphoblastic leukaemia.Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptorSALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic miceMyeloid malignancies: mutations, models and managementAn overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatmentFLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications.Misguided transcriptional elongation causes mixed lineage leukemiaThe origin and evolution of mutations in acute myeloid leukemiaThe t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1.Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.Comprehensive mutational profiling of core binding factor acute myeloid leukemia.The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulationDasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasmsDistinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia.Molecular therapeutic approaches to acute myeloid leukemia: targeting aberrant chromatin dynamics and signal transduction.The ETS factor TEL2 is a hematopoietic oncoprotein.Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.Dynamic single-cell network profiles in acute myelogenous leukemia are associated with patient response to standard induction therapyMyeloproliferative disorders: the centrosome connection.Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.Does autologous transplantation directly increase the risk of secondary leukemia in lymphoma patients?Cytogenetic and FMS-like tyrosine kinase 3 mutation analyses in acute promyelocytic leukemia patients.Involvement of KRAS G12A mutation in the IL-2-independent growth of a human T-LGL leukemia cell line, PLT-2.The myelodysplastic syndrome as a prototypical epigenetic diseaseMolecular mechanisms of drug resistance in acute myeloid leukaemia.Hematopoietic developmental pathways: on cellular basis.All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo.MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.The microRNAs involved in human myeloid differentiation and myelogenous/myeloblastic leukemia.Is the focus moving toward a combination of targeted drugs?Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors.Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.Exploiting cellular pathways to develop new treatment strategies for AML.Role and potential for therapeutic targeting of MYB in leukemia.AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.
P2860
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P2860
Molecular genetics of human leukemias: new insights into therapy.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Molecular genetics of human leukemias: new insights into therapy.
@ast
Molecular genetics of human leukemias: new insights into therapy.
@en
Molecular genetics of human leukemias: new insights into therapy.
@nl
type
label
Molecular genetics of human leukemias: new insights into therapy.
@ast
Molecular genetics of human leukemias: new insights into therapy.
@en
Molecular genetics of human leukemias: new insights into therapy.
@nl
prefLabel
Molecular genetics of human leukemias: new insights into therapy.
@ast
Molecular genetics of human leukemias: new insights into therapy.
@en
Molecular genetics of human leukemias: new insights into therapy.
@nl
P356
P1476
Molecular genetics of human leukemias: new insights into therapy.
@en
P2093
D Gary Gilliland
P356
10.1053/SHEM.2002.36921
P433
P577
2002-10-01T00:00:00Z