Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
about
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammalsBuilding dialogues between clinical and biomedical research through cross-species collaborations.Overview of iron metabolism in health and disease.Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.The role of oxidative stress in Friedreich's ataxia.Copper and Zinc Homeostasis: Lessons from Drosophila melanogaster.Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner.Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich's Ataxia.Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.Drosophila melanogaster Models of Friedreich's Ataxia.Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model.Iron in Friedreich Ataxia: A Central Role in the Pathophysiology or an Epiphenomenon?
P2860
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P2860
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@ast
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@en
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@nl
type
label
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@ast
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@en
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@nl
prefLabel
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@ast
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@en
Loss of Frataxin induces iron ...... leading to neurodegeneration.
@nl
P2093
P2860
P50
P356
P1433
P1476
Loss of Frataxin induces iron ...... , leading to neurodegeneration
@en
P2093
Kuchuan Chen
Lita Duraine
Nele A Haelterman
Tammy Szu-Yu Ho
Tongchao Li
Zhihong Li
P2860
P356
10.7554/ELIFE.16043
P407
P577
2016-06-25T00:00:00Z