Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
about
Structure-guided design of selective Epac1 and Epac2 agonistsExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsSomatostatin Depresses the Excitability of Subicular Bursting Cells: Roles of Inward Rectifier K+ Channels, KCNQ channels and Epac.Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Therapeutic Potential of Spirooxindoles as Antiviral AgentsCyclic AMP sensor EPAC proteins and energy homeostasis.The future of EPAC-targeted therapies: agonism versus antagonismRp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Functionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammationNew insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout miceExchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.Epac-inhibitors: facts and artefacts.On the G protein-coupling selectivity of the native A2B adenosine receptor.Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.Null EPAC mutants reveal a sequential order of versatile cAMP effects during Drosophila aversive odor learning.Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors.
P2860
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P2860
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Identification and characteriz ...... nd specific EPAC2 antagonists.
@ast
Identification and characteriz ...... nd specific EPAC2 antagonists.
@en
Identification and characteriz ...... nd specific EPAC2 antagonists.
@nl
type
label
Identification and characteriz ...... nd specific EPAC2 antagonists.
@ast
Identification and characteriz ...... nd specific EPAC2 antagonists.
@en
Identification and characteriz ...... nd specific EPAC2 antagonists.
@nl
prefLabel
Identification and characteriz ...... nd specific EPAC2 antagonists.
@ast
Identification and characteriz ...... nd specific EPAC2 antagonists.
@en
Identification and characteriz ...... nd specific EPAC2 antagonists.
@nl
P2093
P2860
P356
P1476
Identification and characteriz ...... nd specific EPAC2 antagonists.
@en
P2093
Fang C Mei
George G Holz
Haijun Chen
Oleg G Chepurny
Tamara Tsalkova
Xiaodong Cheng
P2860
P304
P356
10.1021/JM3014162
P407
P577
2013-01-15T00:00:00Z