Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.
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Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's DiseaseBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseMecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disordersNicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptorsChotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.Methyllycaconitine- and scopolamine-induced cognitive dysfunction: differential reversal effect by cognition-enhancing drugs.Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats17β-Oestradiol Protects Primary-Cultured Rat Cortical Neurons from Ketamine-Induced Apoptosis by Activating PI3K/Akt/Bcl-2 Signalling.Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxidePI3K/Akt signal pathway involved in the cognitive impairment caused by chronic cerebral hypoperfusion in rats.CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer's diseaseActivation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.The effects of postnatal alcohol exposure and galantamine on the context pre-exposure facilitation effect and acetylcholine efflux using in vivo microdialysis.Broader considerations of higher doses of donepezil in the treatment of mild, moderate, and severe Alzheimer's disease.Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes.New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy.Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity.Donepezil: an update.Alterations in Cholinergic Pathways and Therapeutic Strategies Targeting Cholinergic System after Traumatic Brain Injury.Beyond symptomatic therapy: a re-examination of acetylcholinesterase inhibitors in Alzheimer's disease.Donepezil for Alzheimer's disease.An update on the pharmacology of galantamine.Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease.Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?Opioid system and Alzheimer's disease.Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces.α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats.Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway.L-3-n-butylphthalide improves cognitive impairment of APP/PS1 mice by BDNF/TrkB/PI3K/AKT pathway.Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampusα7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices.Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation.Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity.Anti-Alzheimer's Studies on β-Sitosterol Isolated from Polygonum hydropiper L.Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia.Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.
P2860
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P2860
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@ast
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@en
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@nl
type
label
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@ast
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@en
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@nl
prefLabel
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@ast
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@en
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@nl
P2093
P1433
P1476
Acetylcholinesterase inhibitor ...... idylinositol 3-kinase cascade.
@en
P2093
Akinori Akaike
Hachiro Sugimoto
Hiroshi Katsuki
Mitsuhiro Sugimoto
Toshiaki Kume
Yuki Takada-Takatori
P304
P356
10.1016/J.NEUROPHARM.2006.04.007
P577
2006-06-08T00:00:00Z