Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. - Wikidata - awgldk - TriplyDB

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.

http://www.wikidata.org/entity/Q34541951

about

Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes.Proposing a mechanism of action for ataluren.The Role of +4U as an Extended Translation Termination Signal in Bacteria.Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity The nucleoside analog clitocine is a potent and efficacious readthrough agent.Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation.Self-Referential Encoding on Modules of Anticodon Pairs-Roots of the Biological Flow System.Ataluren in cystic fibrosis: development, clinical studies and where are we now?Efficacy of Postnatal In Vivo Nonsense Suppression Therapy in a Pax6 Mouse Model of Aniridia.Phase I and II clinical trials for the mucopolysaccharidoses.Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle.Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences.Analysis of Azithromycin Monohydrate as a Single or a Combinatorial Therapy in a Mouse Model of Severe Spinal Muscular Atrophy.Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons.The effect of PTC124 on choroideremia fibroblasts and iPSC-derived RPE raises considerations for therapy.Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons.Variants: Association With Cardiac Disorders

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P2860

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.

http://www.wikidata.org/entity/Q34541951

description

2016 nî lūn-bûn

@nan

2016 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

name

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@ast

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@en

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@nl

type

label

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@ast

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@en

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@nl

prefLabel

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@ast

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@en

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@nl

P1433

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P356

PNAS.1605336113

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Ataluren stimulates ribosomal ...... promote nonsense suppression.

@en

P2093

Allan Jacobson

http://www.w3.org/2001/XMLSchema#string

Bijoyita Roy

http://www.w3.org/2001/XMLSchema#string

Briana Johnson

http://www.w3.org/2001/XMLSchema#string

Christopher R Trotta

http://www.w3.org/2001/XMLSchema#string

David M Bedwell

http://www.w3.org/2001/XMLSchema#string

Ellen M Welch

http://www.w3.org/2001/XMLSchema#string

James A Mobley

http://www.w3.org/2001/XMLSchema#string

Jin Zhuo

http://www.w3.org/2001/XMLSchema#string

John D Leszyk

http://www.w3.org/2001/XMLSchema#string

Jumana Dakka

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate

Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor

Safety, tolerability, and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single- and multiple-dose administration to healthy male and female adult volunteers.

PTC124 targets genetic disorders caused by nonsense mutations.

An evolutionarily conserved mechanism for controlling the efficiency of protein translation.

Postnatal manipulation of Pax6 dosage reverses congenital tissue malformation defects.

Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability.

P304

12508-12513

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scholarly article

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10.1073/PNAS.1605336113

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P407

P433

44

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P478

113

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2016-10-04T00:00:00Z

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27702906

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P932

5098639

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