Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.

Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.

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http://www.wikidata.org/entity/Q34546037

Q34546037

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Nonhuman primate models for HIV/AIDS vaccine development Poxvirus vectors as HIV/AIDS vaccines in humans The evolution of poxvirus vaccines Synthetic DNA vaccine strategies against persistent viral infections HIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine development HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development.Vaccine design for CD8 T lymphocyte responses Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization.Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolate.Both systemic and mucosal LCMV immunization generate robust viral-specific IgG in mucosal secretions, but elicit poor LCMV-specific IgA.Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles.Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials.Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection.Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform "spotty business".Generation of functionally active HIV-1 specific CD8+ CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization.Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure.A new era in HIV vaccine development.Oral vaccination with modified vaccinia virus Ankara attached covalently to TMPEG-modified cationic liposomes overcomes pre-existing poxvirus immunity from recombinant vaccinia immunization.Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency.Systemic and mucosal infection program protective memory CD8 T cells in the vaginal mucosa.Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV.Prime-boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1.Human immunodeficiency virus-1 vaccine design: where do we go now?Type I interferons in regulation of mucosal immunity.HIV vaccine research and discovery in the nonhuman primates model: a unified theory in acquisition prevention and control of SIV infection Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines.Prime-boost vaccination with a combination of proteosome-degradable and wild-type forms of two influenza proteins leads to augmented CTL response.Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011.Extended evaluation of the virologic, immunologic, and clinical course of volunteers who acquired HIV-1 infection in a phase III vaccine trial of ALVAC-HIV and AIDSVAX B/E.CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection.Lack of IL-7 and IL-15 signaling affects interferon-γ production by, more than survival of, small intestinal intraepithelial memory CD8+ T cells.

P2860

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P2860

Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.

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