p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. - Wikidata - awgldk - TriplyDB

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

http://www.wikidata.org/entity/Q34547830

about

Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Clinical update on cancer: molecular oncology of head and neck cancer Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS.Identification of potential synthetic lethal genes to p53 using a computational biology approach The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs Towards an understanding of the role of p53 in adrenocortical carcinogenesis.Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action.Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu).TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma.PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells The Role of p53 and MDM2 in Head and Neck Cancer.p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice.Pharmacological activation of p53 in cancer cells Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer.p53-based therapeutics for head and neck squamous cell carcinoma E3 ubiquitin ligases and human papillomavirus-induced carcinogenesis.Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo.XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer.PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines.Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells.STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7.Proteasome-associated deubiquitinases and cancer.PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.Novel p53 therapies for head and neck cancer.

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P2860

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

http://www.wikidata.org/entity/Q34547830

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@ast

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@en

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@nl

type

label

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@ast

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@en

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@nl

prefLabel

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@ast

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@en

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@nl

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J.ORALONCOLOGY.2010.10.011

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P1476

p53-Reactivating small molecul ...... neck squamous cell carcinoma.

@en

P2093

David Sidransky

http://www.w3.org/2001/XMLSchema#string

Il Minn

http://www.w3.org/2001/XMLSchema#string

Jong-Lyel Roh

http://www.w3.org/2001/XMLSchema#string

Joseph A Califano

http://www.w3.org/2001/XMLSchema#string

Sung Koo Kang

http://www.w3.org/2001/XMLSchema#string

Wayne M Koch

http://www.w3.org/2001/XMLSchema#string

P2860

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

p53, the cellular gatekeeper for growth and division

Cancer genes and the pathways they control

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Blinded by the Light: The Growing Complexity of p53

Live or let die: the cell's response to p53

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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8-15

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scholarly article

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10.1016/J.ORALONCOLOGY.2010.10.011

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1

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2010-12-15T00:00:00Z

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49637533

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21109480

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P921

head and neck squamous cell carcinoma

P932

3032831

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