about
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expressionRegulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8Structural basis of the recognition of a methylated histone tail by JMJD2APro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repressionThe PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesisMenin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsCovalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersE2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferasesDistinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosminTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyEpigenomics of leukemia: from mechanisms to therapeutic applicationsPartners in crime: The role of tandem modules in gene transcriptionDiverse functions of PHD fingers of the MLL/KMT2 subfamilyMolecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM DomainStructural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.Potent inhibition of DOT1L as treatment of MLL-fusion leukemiaHigh-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionProperty Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Role of HOXA9 in leukemia: dysregulation, cofactors and essential targetsEpigenome-based personalized medicine in human cancerGenomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancerClinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise reviewMisguided transcriptional elongation causes mixed lineage leukemiaCo-regulation of histone-modifying enzymes in cancerInfertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemiaDisruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaAlu recombination-mediated structural deletions in the chimpanzee genome.Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemiaProtein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms.Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesisPhosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry.Zebrafish mll gene is essential for hematopoiesis.MLL associates specifically with a subset of transcriptionally active target genes.Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
MLL: a histone methyltransferase disrupted in leukemia.
@ast
MLL: a histone methyltransferase disrupted in leukemia.
@en
MLL: a histone methyltransferase disrupted in leukemia.
@nl
type
label
MLL: a histone methyltransferase disrupted in leukemia.
@ast
MLL: a histone methyltransferase disrupted in leukemia.
@en
MLL: a histone methyltransferase disrupted in leukemia.
@nl
prefLabel
MLL: a histone methyltransferase disrupted in leukemia.
@ast
MLL: a histone methyltransferase disrupted in leukemia.
@en
MLL: a histone methyltransferase disrupted in leukemia.
@nl
P1476
MLL: a histone methyltransferase disrupted in leukemia.
@en
P2093
Jay L Hess
P304
P356
10.1016/J.MOLMED.2004.08.005
P577
2004-10-01T00:00:00Z