Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. - Wikidata - awgldk - TriplyDB

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

http://www.wikidata.org/entity/Q34562010

about

Germline mutations in TMEM127 confer susceptibility to pheochromocytoma Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR Emerging pharmacotherapies for neurodevelopmental disorders Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Familial syndromes associated with neuroendocrine tumours Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysis The expanding role of mTOR in cancer cell growth and proliferation Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC)Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation Downregulation of Rap1GAP contributes to Ras transformation Tuberous sclerosis complex proteins control axon formation A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma.Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.Ras and Rap signaling in synaptic plasticity and mental disorders.Endocrine tumours in neurofibromatosis type 1, tuberous sclerosis and related syndromes Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions.Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.Molecular and clinical analyses of 84 patients with tuberous sclerosis complex.Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis.

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

http://www.wikidata.org/entity/Q34562010

description

2005 nî lūn-bûn

@nan

2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

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name

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@ast

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@en

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@nl

type

label

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@ast

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@en

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@nl

prefLabel

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@ast

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@en

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@nl

P1433

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P2860

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Q34562010-BD174B7C-AE0D-41A5-9392-9049C713F82D

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Q34562010-57095B75-93A2-4EF8-BE62-D179521A46CF

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Q34562010-A2953530-D765-4771-841D-FB44F8A7B75D

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P356

P1433

Human Molecular Genetics

P1476

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

@en

P2093

Brendan D Manning

http://www.w3.org/2001/XMLSchema#string

David J Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Signaling by target of rapamycin proteins in cell growth control

P304

R251-8

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P31

scholarly article

P356

10.1093/HMG/DDI260

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P478

14 Spec No. 2

http://www.w3.org/2001/XMLSchema#string

P577

2005-10-01T00:00:00Z

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P5875

7522910

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P698

16244323

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