Strategies for absorption screening in drug discovery and development.
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Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsPrediction of the permeability of neutral drugs inferred from their solvation propertiesMechanistic approaches to predicting oral drug absorption.Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models.Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.Enhanced solubility and intestinal absorption of candesartan cilexetil solid dispersions using everted rat intestinal sacsA chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challengesDetermination of fexofenadine in Hank's balanced salt solution by high-performance liquid chromatography with ultraviolet detection: application to Caco-2 cell permeability studies.In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach.Strategies to improve oral drug bioavailability.Caco-2 cell permeability assays to measure drug absorption.Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Modeling kinetics of subcellular disposition of chemicals.Mitigating permeability-mediated risks in drug discovery.Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling.Application of method suitability for drug permeability classification.Cell-based in vitro models for predicting drug permeability.Using artificial neural networks to predict cell-penetrating compounds.Experimental models for predicting drug absorption and metabolism.Relevance of the Pharmacokinetic and Pharmacodynamic Profiles of Puerariae lobatae Radix to Aggregation of Multi-Component Molecules in Aqueous Decoctions.Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue.Cells on pores: a simulation-driven analysis of transcellular small molecule transport.Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.Ethyl 4-(4-methylphenyl)-4-pentenoate from Vetiveria zizanioides Inhibits Dengue NS2B-NS3 Protease and Prevents Viral Assembly: A Computational Molecular Dynamics and Docking Study.Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs.A Molecular Docking and Dynamics Study to Screen Potent Anti-Staphylococcal Compounds Against Ceftaroline Resistant MRSA.High glucose concentration in isotonic media alters caco-2 cell permeability.An evaluation of the relative roles of the unstirred water layer and receptor sink in limiting the in-vitro intestinal permeability of drug compounds of varying lipophilicity.Improved oral bioavailability of BCS class 2 compounds by self nano-emulsifying drug delivery systems (SNEDDS): the underlying mechanisms for amiodarone and talinolol.Orthogonal chromatographic descriptors for modelling Caco-2 drug permeability.Characterization of the absorption of theophylline from immediate- and controlled-release dosage forms with a numerical approach using the in vitro dissolution-permeation process using caco-2 cells.Synthesis of novel benzimidazole acrylonitriles for inhibition of Plasmodium falciparum growth by dual target inhibition.The advantages of the Ussing chamber in drug absorption studies.Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs.Guidance for submission for food additive evaluationsMolecular clusters size of Puerariae thomsonii radix aqueous decoction and relevance to oral absorption.The Ussing chamber and measurement of drug actions on mucosal ion transport.Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.
P2860
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P2860
Strategies for absorption screening in drug discovery and development.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Strategies for absorption screening in drug discovery and development.
@ast
Strategies for absorption screening in drug discovery and development.
@en
Strategies for absorption screening in drug discovery and development.
@nl
type
label
Strategies for absorption screening in drug discovery and development.
@ast
Strategies for absorption screening in drug discovery and development.
@en
Strategies for absorption screening in drug discovery and development.
@nl
prefLabel
Strategies for absorption screening in drug discovery and development.
@ast
Strategies for absorption screening in drug discovery and development.
@en
Strategies for absorption screening in drug discovery and development.
@nl
P2093
P356
P1476
Strategies for absorption screening in drug discovery and development.
@en
P2093
Lavrijsen K
Meuldermans W
Van Beijsterveldt L
Verboven P
P304
P356
10.2174/1568026013394886
P577
2001-11-01T00:00:00Z