Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not with vimentin. Immunoelectron microscopy with colloidal gold.
about
GFAP and its role in Alexander diseaseInteractive domains in the molecular chaperone human alphaB crystallin modulate microtubule assembly and disassemblyGFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander diseaseThe twelfth Frederick H. Verhoeff Lecture: gene sharing in the visual system.Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease modelThe Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27Alpha-crystallin/small heat shock protein has autokinase activity.Formation of GFAP cytoplasmic inclusions in astrocytes and their disaggregation by alphaB-crystallin.Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers.Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander diseaseAlexander Disease: A Novel Mutation in GFAP Leading to Epilepsia Partialis ContinuaNovel roles for α-crystallins in retinal function and disease.Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes.Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation.Juvenile alexander disease: a case report.Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions.Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filamentsAlexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature OligodendrocytesTransactivation response DNA-binding protein 43 microvasculopathy in frontotemporal degeneration and familial Lewy body disease.Rosenthal fibers contain ubiquitinated alpha B-crystallin
P2860
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P2860
Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not with vimentin. Immunoelectron microscopy with colloidal gold.
description
1991 nî lūn-bûn
@nan
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@ast
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@en
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@nl
type
label
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@ast
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@en
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@nl
prefLabel
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@ast
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@en
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@nl
P2093
P2860
P1476
Rosenthal fibers share epitope ...... icroscopy with colloidal gold.
@en
P2093
P2860
P304
P407
P577
1991-04-01T00:00:00Z