MCL-1 localizes to sites of DNA damage and regulates DNA damage response - Wikidata - awgldk - TriplyDB

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

http://www.wikidata.org/entity/Q34582160

about

Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress BID binds to replication protein A and stimulates ATR function following replicative stress Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage.Targeting mcl-1 for radiosensitization of pancreatic cancers.MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response Bcl-xL is an oncogenic driver in colorectal cancer.MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.Idelalisib and bendamustine combination is synergistic and increases DNA damage response in chronic lymphocytic leukemia cells.The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage.Etoposide induces cell death via mitochondrial-dependent actions of p53.Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence.Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.Failure to Inactivate Nuclear GSK3β by Ser389-Phosphorylation Leads to Focal Neuronal Death and Prolonged Fear Response.The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer.

P2860

Q24620829-41D20CD1-01FB-4B69-BF7C-B241152823EC Q24631191-6E6D7891-699E-4489-B6D1-E53BAEF89F8D Q34307356-26078687-E04A-4DA1-B62A-E71BC58E02CF Q34425246-9C994385-CBA8-4C5C-93B5-93D1A72C3514 Q35007971-5E484F9A-CF01-4F01-9771-6A519A9CD2CA Q35150651-0382AE98-7D67-483D-A28B-7C8CF7E6E917 Q36184998-A3B94FD1-234D-45FE-B4AB-B4BC1493E35C Q36540443-6546B939-BF8B-4E0A-98E6-13E0E744B230 Q37412492-27CA1CEB-DE8C-4235-821D-0DEF140D2A3D Q37487789-468EA614-7D89-4F4D-9503-6C4BCB1E33C3 Q37725415-9055B650-AE15-499F-94CC-187E1E1BC019 Q38722941-EB032D54-B442-49AD-86A1-A673E948572E Q41694352-7EEDDCAD-87B1-47B1-B8FC-060F45A6F296 Q41845149-1470FC62-7995-4EA4-91AC-6EEE8A69F01F Q41850633-81A022E2-4F89-42BD-BFCE-7A473E9494BB Q42254401-8806B6EC-A569-4F80-84E6-501896CC8912 Q46339972-81C1FA34-F15A-403A-B228-F80EDCF2AC74 Q47308626-00304402-54AE-4AB3-AD6F-6F45B9533106 Q47373137-C0EEE14A-4155-41DC-B6A0-DB604CCBD97C Q47790879-EF91A424-66BD-4A8E-93DC-19E88CEF94F3 Q48121335-AAEE96FA-ECE9-4221-86F9-3F8C25E3E018 Q49335222-AC46CFFA-9FCA-4225-BDF6-FEE6A4A3E4E9 Q53733720-41F93F1C-9601-40A1-8554-752AF46C23C4

P2860

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

http://www.wikidata.org/entity/Q34582160

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@ast

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@en

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@nl

type

label

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@ast

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@en

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@nl

prefLabel

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@ast

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@en

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@nl

P1433

Q34582160-F0F2F9C1-3479-4349-B252-C57F4CD320FA

P1476

Q34582160-918F4D34-0109-465B-ACE6-A4E637B6A8D1

P2093

Q34582160-2CE874AF-2AD6-49EE-9AC4-9D2D9E2D95F8

Q34582160-80816CBC-6BE2-4EC8-83B5-851122AF2B64

Q34582160-C1E3B9DD-3C94-409A-B7F3-A449972F146D

Q34582160-D241BB40-19B3-4526-8CD9-CF33B4DA5CCC

P2860

Q34582160-0175944B-37ED-479A-A108-2201E389A1D9

Q34582160-022ECF11-6E5B-40BE-A6C1-4AEB6D8A86AC

Q34582160-03C4B69E-8C24-43A9-BC00-12A110C6F4A1

Q34582160-06222D2F-C9D8-4E49-8766-EAAE1CDFBBF7

Q34582160-0C24D5A6-D4E7-455F-8164-E84F385E4D81

Q34582160-114C6D16-ED17-4442-B875-B2DF120701B5

Q34582160-167440FC-CAEC-4269-9E5C-A2BE8B8FF966

Q34582160-1BBEE433-D229-486A-8C1F-4D51F3E1DB53

Q34582160-2934890C-43A5-478A-BB35-3D9942D31A8F

Q34582160-296FA44A-6705-4F11-A00F-9EB785073616

P304

Q34582160-F239F342-0758-42D1-8485-19B7699D4492

P31

Q34582160-DD4C3C81-C6A8-48BE-A6EC-8BD67F159D36

P356

Q34582160-BE46DFBC-DC56-47BD-AB90-4E822A3F9BC5

P433

Q34582160-C7BD2B73-D973-4B1D-9C44-44CC4D771449

P478

Q34582160-6798621C-D105-44D7-A5F7-1E38D22A5D0D

P577

Q34582160-C131D638-DCFD-4408-98F9-C663A3CAECA0

P5875

Q34582160-91111DC5-809B-462B-B635-C9A2AC394E7F

P698

Q34582160-3D2F8CAF-3541-4D70-819E-062439496E1D

P921

Q34582160-420DA533-FA6E-46FF-95AF-434F70112651

P932

Q34582160-F7904350-8DB5-4A89-9BB7-CD32DEEC1808

P356

P1433

P1476

MCL-1 localizes to sites of DNA damage and regulates DNA damage response

@en

P2093

Cezar Stoica

http://www.w3.org/2001/XMLSchema#string

Sarwat Jamil

http://www.w3.org/2001/XMLSchema#string

Tillie-Louise Hackett

http://www.w3.org/2001/XMLSchema#string

Vincent Duronio

http://www.w3.org/2001/XMLSchema#string

P2860

The BRCT domain is a phospho-protein binding domain

Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

Megabase chromatin domains involved in DNA double-strand breaks in vivo

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.

The DNA damage response: putting checkpoints in perspective

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

P304

2843-2855

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.4161/CC.9.14.12354

http://www.w3.org/2001/XMLSchema#string

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

9

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45278871

http://www.w3.org/2001/XMLSchema#string

P698

20647761

http://www.w3.org/2001/XMLSchema#string

P921

P932

3040962

http://www.w3.org/2001/XMLSchema#string