Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes - Wikidata - awgldk - TriplyDB

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

http://www.wikidata.org/entity/Q34583590

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Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?Recent progress in genetic and epigenetic research on type 2 diabetes New insights from monogenic diabetes for "common" type 2 diabetes Testing the role of predicted gene knockouts in human anthropometric trait variation The genetic architecture of type 2 diabetes Human genetics as a model for target validation: finding new therapies for diabetes.PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice.Diabetes mellitus: The epidemic of the century.Rare variant association studies: considerations, challenges and opportunities.Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies Family-based approaches: design, imputation, analysis, and beyond.Recent advances in understanding the genetic architecture of type 2 diabetes Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity Prospective functional classification of all possible missense variants in PPARG.De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease.Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.PPARγ mutations, lipodystrophy and diabetes.The genetics of diabetic complications.Mechanisms of Type 2 Diabetes Risk Loci.The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research.An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics.Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations?When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes.The power of multiplexed functional analysis of genetic variants.Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.Epigenomic and transcriptional control of insulin resistance.Distinct but complementary contributions of PPAR isotypes to energy homeostasis.Genetic disorders of nuclear receptors.Systematic Cell-Based Phenotyping of Missense Alleles.Determinants of Power in Gene-Based Burden Testing for Monogenic Disorders.Massively Parallel Genetics.Life after genetics.Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals.Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

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P2860

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

http://www.wikidata.org/entity/Q34583590

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Rare variants in PPARG with de ...... reased risk of type 2 diabetes

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Rare variants in PPARG with de ...... reased risk of type 2 diabetes

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Rare variants in PPARG with de ...... reased risk of type 2 diabetes

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Rare variants in PPARG with de ...... reased risk of type 2 diabetes

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PNAS.1410428111

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Proceedings of the National Academy of Sciences of the United States of America

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P2093

Amit R Majithia

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Evan D Rosen

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GoT2D Consortium

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Jason Flannick

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Mark-Anthony Bray

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Michael Guo

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NHGRI JHS/FHS Allelic Spectrum Project

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Peter Shahinian

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Pierre Fontanillas

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SIGMA T2D Consortium

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P2860

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

A high-resolution map of human evolutionary constraint using 29 mammals

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

A map of human genome variation from population-scale sequencing

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism

Evolution and functional impact of rare coding variation from deep sequencing of human exomes

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.

Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel.

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13127-13132

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scholarly article

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10.1073/PNAS.1410428111

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36

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111

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David Altshuler

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2014-08-25T00:00:00Z

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265057277

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25157153

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type-2 diabetes

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4246964

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