The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies - Wikidata - awgldk - TriplyDB

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

http://www.wikidata.org/entity/Q34587678

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Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Therapeutic and diagnostic challenges for frontotemporal dementia Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy.Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers.Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy Cancer and Dementia: It's Complicated.The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.Paclitaxel improves outcome from traumatic brain injury.A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research.Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies Direct modulation of microtubule stability contributes to anthracene general anesthesia.Tau as a therapeutic target in neurodegenerative disease.Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro Microtubule stabilising peptides rescue tau phenotypes in-vivo.Back to the tubule: microtubule dynamics in Parkinson's disease.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Modelling tauopathies in Drosophila: insights from the fruit fly.A novel role for retrograde transport of microtubules in the axon.Towards understanding the phosphorylation code of tau.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.A review: treatment of Alzheimer's disease discovered in repurposed agents.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.Therapeutic Strategies for Restoring Tau Homeostasis.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks.

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The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

http://www.wikidata.org/entity/Q34587678

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The characterization of microt ...... isease and related tauopathies

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The characterization of microt ...... isease and related tauopathies

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The characterization of microt ...... isease and related tauopathies

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The characterization of microt ...... isease and related tauopathies

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J.PHRS.2010.12.002

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Pharmacological Research

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The characterization of microt ...... isease and related tauopathies

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Amos B Smith

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Anne-Marie L Hogan

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Carlo Ballatore

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Justin S Potuzak

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Kurt R Brunden

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Michael J James

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Nuria Ibarz Ferrer

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Virginia M-Y Lee

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Yuemang Yao

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P2860

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

Neurodegenerative tauopathies

Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins

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341-351

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scholarly article

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10.1016/J.PHRS.2010.12.002

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4

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63

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John Q. Trojanowski

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2010-12-14T00:00:00Z

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49688305

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21163349

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Alzheimer's disease

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3042036

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