The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies
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Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathiesThe Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeletonMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsTherapeutic and diagnostic challenges for frontotemporal dementiaDexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseNAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy.Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers.Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsChronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathyCancer and Dementia: It's Complicated.The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease.Paclitaxel improves outcome from traumatic brain injury.A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research.Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related TauopathiesDirect modulation of microtubule stability contributes to anthracene general anesthesia.Tau as a therapeutic target in neurodegenerative disease.Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitroMicrotubule stabilising peptides rescue tau phenotypes in-vivo.Back to the tubule: microtubule dynamics in Parkinson's disease.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Modelling tauopathies in Drosophila: insights from the fruit fly.A novel role for retrograde transport of microtubules in the axon.Towards understanding the phosphorylation code of tau.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.A review: treatment of Alzheimer's disease discovered in repurposed agents.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.Therapeutic Strategies for Restoring Tau Homeostasis.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks.
P2860
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P2860
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The characterization of microt ...... isease and related tauopathies
@ast
The characterization of microt ...... isease and related tauopathies
@en
The characterization of microt ...... isease and related tauopathies
@nl
type
label
The characterization of microt ...... isease and related tauopathies
@ast
The characterization of microt ...... isease and related tauopathies
@en
The characterization of microt ...... isease and related tauopathies
@nl
prefLabel
The characterization of microt ...... isease and related tauopathies
@ast
The characterization of microt ...... isease and related tauopathies
@en
The characterization of microt ...... isease and related tauopathies
@nl
P2093
P2860
P1476
The characterization of microt ...... isease and related tauopathies
@en
P2093
Amos B Smith
Anne-Marie L Hogan
Carlo Ballatore
Justin S Potuzak
Kurt R Brunden
Michael J James
Nuria Ibarz Ferrer
Virginia M-Y Lee
Yuemang Yao
P2860
P304
P356
10.1016/J.PHRS.2010.12.002
P577
2010-12-14T00:00:00Z