Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
about
The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphataseMicroinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytesKSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptorInsulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivoStudies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mappingA vesicle surface tyrosine kinase regulates phagosome maturationIntermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.Properties of the insulin receptor ectodomainT-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1.Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor moleculesIntrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studiesMonoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo.Functionally distinct insulin receptors generated by tissue-specific alternative splicing.Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance."DFG-flip" in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop.Stat5 is a physiological substrate of the insulin receptor.Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expressionAntibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptorEffect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytesReconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transportersInsulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits.Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanismsInsulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes.Molecular genetics of severe insulin resistanceInsulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
P2860
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P2860
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
description
1987 nî lūn-bûn
@nan
1987 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Replacement of lysine residue ...... and receptor kinase activity.
@en
Replacement of lysine residue ...... and receptor kinase activity.
@nl
type
label
Replacement of lysine residue ...... and receptor kinase activity.
@en
Replacement of lysine residue ...... and receptor kinase activity.
@nl
prefLabel
Replacement of lysine residue ...... and receptor kinase activity.
@en
Replacement of lysine residue ...... and receptor kinase activity.
@nl
P2093
P2860
P921
P356
P1476
Replacement of lysine residue ...... and receptor kinase activity.
@en
P2093
S B Pierce
W J Rutter
P2860
P304
P356
10.1073/PNAS.84.3.704
P407
P577
1987-02-01T00:00:00Z