Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.
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Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading processHuman TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and humanA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationMutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyriaThe effect of variation in expression of the candidate dyslexia susceptibility gene homolog Kiaa0319 on neuronal migration and dendritic morphology in the rat.Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migrationThe cytoskeletal arrangements necessary to neurogenesisGenes and brain malformations associated with abnormal neuron positioningCellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migrationAxonal transport: cargo-specific mechanisms of motility and regulationGenetics in non-genetic model systemsExtracellular and Intracellular Signaling for Neuronal PolarityNeuronal migration and its disorders affecting the CA3 regionIn vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampusDoublecortin knockout mice show normal hippocampal-dependent memory despite CA3 lamination defectsGenetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegansMicrotubules and Lis-1/NudE/dynein regulate invasive cell-on-cell migration in DrosophilaReversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface.Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolutionGenetic Basis of Brain MalformationsMutations in the neuronal ß-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defectsBeta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdownSUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in miceMice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizuresUner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stabilityA tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditionsDisturbances in the positioning, proliferation and apoptosis of neural progenitors contribute to subcortical band heterotopia formation.Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutantMutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.New insights into behaviour using mouse ENU mutagenesisCytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway.Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation.Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans.Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.
P2860
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P2860
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@ast
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@en
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@nl
type
label
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@ast
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@en
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@nl
prefLabel
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@ast
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@en
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@nl
P2093
P2860
P50
P1433
P1476
Mutations in alpha-tubulin cau ...... e and lissencephaly in humans.
@en
P2093
Christian Siebold
Guoling Tian
J Nicholas P Rawlins
Jamel Chelly
James Cleak
Kay E Davies
Maria C Piñon
Martin Fray
Nicholas J Cowan
P2860
P356
10.1016/J.CELL.2006.12.017
P407
P50
P577
2007-01-01T00:00:00Z