Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.
about
Estrogen receptors and human diseaseInsights into granulosa cell tumors using spontaneous or genetically engineered mouse modelsGenetic Models for the Study of Luteinizing Hormone Receptor FunctionInsulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice.Fancf-deficient mice are prone to develop ovarian tumoursElevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortexAn essential role for C/EBPbeta in female reproductionInfertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries.Childhood obesity and its impact on the development of adolescent PCOS.Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient miceAblation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in miceMinireview: physiological and pathological actions of RAS in the ovary.Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells.Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan.Xenograft and Transgenic Mouse Models of Epithelial Ovarian Cancer and Non Invasive Imaging Modalities to Monitor Ovarian Tumor Growth In situ -Applications in Evaluating Novel Therapeutic Agents.Development of a syngeneic mouse model of epithelial ovarian cancer.Clearing the way to implantationTransgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralizationPoint mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responsesThe consequences of mutations in the reproductive endocrine system.Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.Targeting gonadotropins: an alternative option for Alzheimer disease treatment.Luteinizing hormone receptor deficiency increases the susceptibility to alkylating agent-induced lymphomagenesis in mice.Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumorsEB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancerEstrogen receptor knockout mice: phenotypes in the female reproductive tract.Animal models for aberrations of gonadotropin action.Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances.Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS).Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutantsConstitutively active luteinizing hormone receptors: consequences of in vivo expression.Differential response to sustained stimulation by hCG & LH on goat ovarian granulosa cells.The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.Mechanisms of hormone-mediated carcinogenesis of the ovary.Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.Mouse models of adrenocortical tumors.Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility.Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome
P2860
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P2860
Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@ast
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@en
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@nl
type
label
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@ast
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@en
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@nl
prefLabel
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@ast
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@en
Targeted overexpression of lut ...... c ovaries, and ovarian tumors.
@nl
P2093
P2860
P356
P1476
Targeted overexpression of lut ...... ic ovaries, and ovarian tumors
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.5.1322
P407
P577
1995-02-01T00:00:00Z