Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.
about
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyCrystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5Matrix Metalloproteinases in Non-Neoplastic Disorders.Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug TargetsThe role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritisCochlin produced by follicular dendritic cells promotes antibacterial innate immunityIdentification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro.Mechanical load inhibits IL-1 induced matrix degradation in articular cartilageLXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Cloning and expression of ADAM-related metalloproteases in equine laminitisADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Joint pathology and platelet-rich plasma therapies.Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpiLeptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cellsThe structure and function of the pericellular matrix of articular cartilage.A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regenerationGlucan HBP-A increase type II collagen expression of chondrocytes in vitro and tissue engineered cartilage in vivo.A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme ExpressionProteases involved in cartilage matrix degradation in osteoarthritis.Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharidesInvolvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageDiscovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.Epigenetic mechanisms underlying the aberrant catabolic and anabolic activities of osteoarthritic chondrocytes.Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect.Increased expression of ADAMTS13 mRNA correlates with ischemic cerebrovascular disease in systemic lupus erythematosus patients.New findings in osteoarthritis pathogenesis: therapeutic implications.Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersAn in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system.Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints.Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.
P2860
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P2860
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@ast
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@en
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@nl
type
label
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@ast
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@en
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@nl
prefLabel
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@ast
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@en
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5.
@nl
P2093
P356
P1476
Aggrecan degradation in human ...... by both ADAMTS-4 and ADAMTS-5
@en
P2093
David W Griggs
Elizabeth C Arner
James T Alston
Micky D Tortorella
Ruo-Hua Song
Zhiyong Yang
P304
P356
10.1002/ART.22334
P577
2007-02-01T00:00:00Z