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Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathiesMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseBeyond taxanes: the next generation of microtubule-targeting agentsEpothilones: From discovery to clinical trialsEpothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers.Enzymatic synthesis of epothilone A glycosidesEthyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis.Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migrationPhase I/II study of sagopilone (ZK-EPO) plus carboplatin in women with recurrent platinum-sensitive ovarian cancer.Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expressionThe microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.Orally bioavailable tubulin antagonists for paclitaxel-refractory cancer.Planctomycetes as Novel Source of Bioactive Molecules.Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors.Phase II trial of patupilone in patients with brain metastases from breast cancer.Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma.Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells.Microbial-based therapy of cancer: current progress and future prospects.Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer.Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Novel microtubule-targeting agents - the epothilones.
@ast
Novel microtubule-targeting agents - the epothilones.
@en
Novel microtubule-targeting agents - the epothilones.
@nl
type
label
Novel microtubule-targeting agents - the epothilones.
@ast
Novel microtubule-targeting agents - the epothilones.
@en
Novel microtubule-targeting agents - the epothilones.
@nl
prefLabel
Novel microtubule-targeting agents - the epothilones.
@ast
Novel microtubule-targeting agents - the epothilones.
@en
Novel microtubule-targeting agents - the epothilones.
@nl
P2093
P2860
P356
P1476
Novel microtubule-targeting agents - the epothilones
@en
P2093
Daniel R Budman
Kit L Cheng
Thomas Bradley
P2860
P304
P356
10.2147/BTT.S3487
P577
2008-12-01T00:00:00Z