Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.
about
Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugatesAndrogen biosynthesis in castration-resistant prostate cancerCrystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate CancerStructure of AKR1C3 with 3-phenoxybenzoic acid boundCrystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancerStructures of complexes of type 5 17β-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor bindingConfounding factors and genetic polymorphism in the evaluation of individual steroid profilingRate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesisSelective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment libraryHuman hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).Non steroidal anti-inflammatory drug use and levels of oestrogens and androgens in men.Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors.Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells.AKR1C3 as a target in castrate resistant prostate cancerRegulation of 17β-hydroxysteroid dehydrogenases in cancer: regulating steroid receptor at pre-receptor stage.Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer.Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.Androgen Signaling in Prostate Cancer.N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.Prostaglandins as PPARγ Modulators in Adipogenesis.Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants.Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily.Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism.Online structure-based screening of purchasable approved drugs and natural compounds: retrospective examples of drug repositioning on cancer targets
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P2860
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@ast
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@en
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase
@nl
type
label
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@ast
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@en
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase
@nl
prefLabel
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@ast
Inhibitors of type 5 17β-hydro ...... rview and structural insights.
@en
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase
@nl
P2860
P1476
Inhibitors of type 5 17β-hydro ...... erview and structural insights
@en
P2093
Michael C Byrns
P2860
P304
P356
10.1016/J.JSBMB.2010.11.004
P577
2010-11-16T00:00:00Z