Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma.
about
Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammationTreatment of allergic asthma: modulation of Th2 cells and their responsesUpdate on anticytokine treatment for asthmaManagement of the patient with eosinophilic asthma: a new era beginsMast cell production and response to IL-4 and IL-13Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse modelDevelopment of pre-clinical models for evaluating the therapeutic potential of candidate siRNA targeting STAT6Differences in candidate gene association between European ancestry and African American asthmatic children.Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island populationTargeting interleukin-4 in asthma: lost in translation?Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.Local and systemic alterations in signal transducers and activators of transcription (STAT) associated with human abdominal aortic aneurysms.Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.Additive anti-allergic effects of anti-interleukin-33 and anti-Siglec-F treatments in a murine model of allergic asthma.Targeting IL4/IL4R for the treatment of epithelial cancer metastasis.IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study.Is suppression of cyst growth in PKD enough to preserve renal function?: STAT6 inhibition is a novel promising target.Stratified approaches to the treatment of asthma.MicroRNA-143 downregulates interleukin-13 receptor alpha1 in human mast cellsEarly infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development.Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma.A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthmaTargeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eyeRegulation of IL-4 receptor signaling by STUB1 in lung inflammation.Autoimmunity as a double agent in tumor killing and cancer promotion.Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonistGene therapy for allergic airway diseases.Pathophysiology of allergic inflammation.The management of asthma and chronic obstructive pulmonary disease: current status and future perspectives.Cytokine pathways in allergic disease.Pathogenesis of severe asthma.Emerging drugs for asthma.HSP: Bystander Antigen in Atopic Diseases?Current concepts of IgE regulation and impact of genetic determinants.Clinical pharmacokinetics of second generation antisense oligonucleotides.Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma.
P2860
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P2860
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Investigational therapeutics t ...... y for the treatment of asthma.
@ast
Investigational therapeutics t ...... y for the treatment of asthma.
@en
Investigational therapeutics t ...... y for the treatment of asthma.
@nl
type
label
Investigational therapeutics t ...... y for the treatment of asthma.
@ast
Investigational therapeutics t ...... y for the treatment of asthma.
@en
Investigational therapeutics t ...... y for the treatment of asthma.
@nl
prefLabel
Investigational therapeutics t ...... y for the treatment of asthma.
@ast
Investigational therapeutics t ...... y for the treatment of asthma.
@en
Investigational therapeutics t ...... y for the treatment of asthma.
@nl
P2093
P1476
Investigational therapeutics t ...... y for the treatment of asthma.
@en
P2093
P356
10.1183/09059180.00007609
P577
2010-03-01T00:00:00Z