Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.
about
Current approaches to studying membrane organizationSeeing and believing: recent advances in imaging cell-cell interactionsShedding light on protein folding, structural and functional dynamics by single molecule studiesKeep on moving: discovering and perturbing the conformational dynamics of enzymesThe dynamical nature of enzymatic catalysis.Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.One-way membrane trafficking of SOS in receptor-triggered Ras activation.Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate.Inhibitors of Ras-SOS Interactions.Stochastic focusing coupled with negative feedback enables robust regulation in biochemical reaction networksThe Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.Plasma membrane regulates Ras signaling networks.Direct observation of proton pumping by a eukaryotic P-type ATPase.Supported lipid bilayers as dynamic platforms for tethered particles.Supported Lipid Bilayers for the Generation of Dynamic Cell-Material Interfaces.Deconstruction of the Ras switching cycle through saturation mutagenesis.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis.Membrane orientation dynamics of lipid-modified small GTPases.Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides.Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation.Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients.Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains.The invariances of power law size distributions.Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions.Dynamic disorder in simple enzymatic reactions induces stochastic amplification of substrate.Detection of Correlated Protein Backbone and Side-Chain Angle Fluctuations.Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes.Rhythmicity and waves in the cortex of single cells.New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.
P2860
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P2860
Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@ast
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@en
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@nl
type
label
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@ast
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@en
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@nl
prefLabel
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@ast
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@en
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@nl
P2093
P2860
P50
P356
P1433
P1476
Molecular kinetics. Ras activa ...... altered fluctuation dynamics.
@en
P2093
Arup K Chakraborty
Cheng-Han Yu
Christopher Rhodes
Jay T Groves
Jodi Gureasko
John Kuriyan
Lars Iversen
Peter Thill
Rebecca S Petit
P2860
P356
10.1126/SCIENCE.1250373
P407
P577
2014-07-01T00:00:00Z