MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.
about
The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancerCondensins: universal organizers of chromosomes with diverse functionsDual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.MCPH1: a window into brain development and evolution.The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex.Condensin II initiates sister chromatid resolution during S phase.A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions.SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeastAn SMC-like protein binds and regulates Caenorhabditis elegans condensins.Self-organization of domain structures by DNA-loop-extruding enzymes.Condensins and 3D Organization of the Interphase Nucleus.Condensin: crafting the chromosome landscape.Chromosome Dynamics during Mitosis.Shaping mitotic chromosomes: From classical concepts to molecular mechanisms.The DNA damage response molecule MCPH1 in brain development and beyond.The functional role for condensin in the regulation of chromosomal organization during the cell cycle.Condensin Regulation of Genome Architecture.The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization.Chromosome structure deficiencies in MCPH1 syndrome.MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis.MCPH1 keeps chromosomes strung out.MCPH1 sequesters condensin IISubunits of human condensins are potential therapeutic targets for cancers.
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P2860
MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@ast
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@en
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@nl
type
label
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@ast
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@en
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@nl
prefLabel
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@ast
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@en
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@nl
P2093
P2860
P50
P356
P1476
MCPH1 regulates chromosome con ...... ite modulator of condensin II.
@en
P2093
Daisuke Yamashita
Detlev Schindler
Heidemarie Neitzel
Marc Trimborn
Tatsuya Hirano
P2860
P304
P356
10.1083/JCB.201106141
P407
P577
2011-09-12T00:00:00Z