Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. - Wikidata - awgldk - TriplyDB

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

http://www.wikidata.org/entity/Q34641201

about

CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex Signaling by the phosphoinositide 3-kinase family in immune cells Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity.Transcriptional control of effector and memory CD8+ T cell differentiation.PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.A central role for Notch in effector CD8(+) T cell differentiation The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection mTOR Links Environmental Signals to T Cell Fate Decisions.The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells FoxO3 is a negative regulator of primary CD8+ T-cell expansion but not of memory formation Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes mTOR and metabolic regulation of conventional and regulatory T cells.T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.Metabolic pathways in T cell fate and function.Signal integration by Akt regulates CD8 T cell effector and memory differentiation.Early changes in the metabolic profile of activated CD8(+) T cells.Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.Regulation and function of mTOR signalling in T cell fate decisions.Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation.FoxO-dependent regulation of diacylglycerol kinase α gene expression The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients The cytotoxic T cell proteome and its shaping by the kinase mTOR.Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes.Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance.Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections

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P2860

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.

http://www.wikidata.org/entity/Q34641201

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Protein kinase B controls tran ...... ensable for T cell metabolism.

@ast

Protein kinase B controls tran ...... ensable for T cell metabolism.

@en

Protein kinase B controls tran ...... ensable for T cell metabolism.

@nl

type

label

Protein kinase B controls tran ...... ensable for T cell metabolism.

@ast

Protein kinase B controls tran ...... ensable for T cell metabolism.

@en

Protein kinase B controls tran ...... ensable for T cell metabolism.

@nl

prefLabel

Protein kinase B controls tran ...... ensable for T cell metabolism.

@ast

Protein kinase B controls tran ...... ensable for T cell metabolism.

@en

Protein kinase B controls tran ...... ensable for T cell metabolism.

@nl

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J.IMMUNI.2011.01.012

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Protein kinase B controls tran ...... ensable for T cell metabolism.

@en

P2093

Carmen Feijoo

http://www.w3.org/2001/XMLSchema#string

Caryll M Waugh

http://www.w3.org/2001/XMLSchema#string

Gavin Preston

http://www.w3.org/2001/XMLSchema#string

Linda V Sinclair

http://www.w3.org/2001/XMLSchema#string

Peter Tamas

http://www.w3.org/2001/XMLSchema#string

P2860

Interleukin-2 receptor signaling: at the interface between tolerance and immunity

mTOR regulates memory CD8 T-cell differentiation

The selectivity of protein kinase inhibitors: a further update

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Kruppel-like factor 2 regulates thymocyte and T-cell migration

TM4: a free, open-source system for microarray data management and analysis

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

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224-236

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scholarly article

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10.1016/J.IMMUNI.2011.01.012

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2

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34

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Doreen Cantrell

Klaus Okkenhaug

David K. Finlay

Andrew N Macintyre

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2011-02-03T00:00:00Z

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49811823

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21295499

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