A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
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Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokersIL-4 and IL-13 signaling in allergic airway diseaseThe multiple-specificity landscape of modular peptide recognition domainsNicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergensExpression of GABAergic receptors in mouse taste receptor cellsRecruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung.Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium.High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.Changes in the mucosal barrier during acute and chronic Trichuris muris infection.Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epitheliumGABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors.CaMKII is essential for the proasthmatic effects of oxidation.Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.Identification and characterization of anesthetic targets by mouse molecular genetics approaches.15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epitheliumAntitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABAB receptor-selective agonistsRole of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.Airway epithelium is a predominant source of endogenous airway GABA and contributes to relaxation of airway smooth muscle tone.Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation.Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation.Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction.Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer.An autocrine γ-aminobutyric acid signaling system exists in pancreatic β-cell progenitors of fetal and postnatal mice.A microfluidics-based in vitro model of the gastrointestinal human-microbe interfaceGABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance.Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma TreatmentsLuteolin inhibits GABAA receptors in HEK cells and brain slicesActivation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation.Low-dose oral cadmium increases airway reactivity and lung neuronal gene expression in mice.Airway Epithelial Cell Release of GABA is Regulated by Protein Kinase A.Luteolin Attenuates Airway Mucus Overproduction via Inhibition of the GABAergic SystemThe GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo.Non-neuronal release of gamma-aminobutyric Acid by embryonic pluripotent stem cells.Oxidant stress promotes disease by activating CaMKII.Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease.
P2860
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P2860
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@ast
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@en
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@nl
type
label
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@ast
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@en
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@nl
prefLabel
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@ast
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@en
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@nl
P2093
P50
P356
P1433
P1476
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
@en
P2093
Beverley Orser
Jeremy A Hirota
Jingxin Li
Margaret M Kelly
Mark D Inman
Shuhe Wang
Wei-Yang Lu
William Ju
P2888
P304
P356
10.1038/NM1604
P407
P577
2007-06-24T00:00:00Z