Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
about
HDP-a novel heme detoxification protein from the malaria parasiteFour distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum.Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaIdentification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational ApproachAsparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections.Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparumStructural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseStructure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 MetalloaminopeptidaseBestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidasesRoles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparumProtein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparumDistribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolismThe glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmissionMining a cathepsin inhibitor library for new antiparasitic drug leadsThe Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulationsA process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparumMetabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolismDisulfide linkages in Plasmodium falciparum plasmepsin-i are essential elements for its processing activity and multi-milligram recombinant production yieldSynergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel InhibitorsEnzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium bergheiSymbiosis as an adaptive process and source of phenotypic complexityBranched tricarboxylic acid metabolism in Plasmodium falciparumIdentification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparumCationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasitesA role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplastPlasmodium falciparum Maf1 Confers Survival upon Amino Acid StarvationPfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin traffickingEsterase mutation is a mechanism of resistance to antimalarial compoundsValidation of isoleucine utilization targets in Plasmodium falciparumCharacterization of the chloroquine resistance transporter homologue in Toxoplasma gondiiGene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors.A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target.Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.Antimalarial activity of azadipeptide nitrilesAntimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysisPredictive Genomic Analyses Inform the Basis for Vitamin Metabolism and Provisioning in Bacteria-Arthropod EndosymbiosesUptake and metabolism of arginine impact Plasmodium development in the liver
P2860
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P2860
Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@ast
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@en
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@nl
type
label
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@ast
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@en
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@nl
prefLabel
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@ast
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@en
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@nl
P2093
P2860
P356
P1476
Plasmodium falciparum ensures ...... ant proteolytic enzyme systems
@en
P2093
Daniel E Goldberg
Eva S Istvan
Ilya Y Gluzman
Julia Gross
P2860
P304
P356
10.1073/PNAS.0601876103
P407
P577
2006-05-26T00:00:00Z