Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. - Wikidata - awgldk - TriplyDB

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

http://www.wikidata.org/entity/Q34648460

about

PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease The role of APP and BACE1 trafficking in APP processing and amyloid-β generation Trafficking regulation of proteins in Alzheimer's disease Caenorhabditis elegans as a model organism to study APP function Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease Alzheimer's pathogenesis and its link to the mitochondrion Toward the structure of presenilin/γ-secretase and presenilin homologs Three-dimensional structure of human γ-secretase Rab GTPases, membrane trafficking and diseases APP processing in Alzheimer's disease An atomic structure of human γ-secretase A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease Assembly, trafficking and function of gamma-secretase Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1 Gamma-secretase complex assembly within the early secretory pathway A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ Tailoring of membrane proteins by alternative splicing of pre-mRNA.Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loci, along with evidence of both genetic and sample heterogeneity.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor Gene expression profiling in cells with enhanced gamma-secretase activity.Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.

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Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

http://www.wikidata.org/entity/Q34648460

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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name

Gamma-secretase is a membrane ...... , nicastrin, Aph-1, and Pen-2.

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Gamma-secretase is a membrane ...... , nicastrin, Aph-1, and Pen-2.

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Gamma-secretase is a membrane ...... , nicastrin, Aph-1, and Pen-2.

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Proceedings of the National Academy of Sciences of the United States of America

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Beth L Ostaszewski

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Dennis J Selkoe

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Matthew J LaVoie

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Michael S Wolfe

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W Taylor Kimberly

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Wenjuan Ye

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P2860

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

Alzheimer's disease: genes, proteins, and therapy

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

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