Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein - Wikidata - awgldk - TriplyDB

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

http://www.wikidata.org/entity/Q34649008

about

PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease The role of APP and BACE1 trafficking in APP processing and amyloid-β generation Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease Trafficking and proteolytic processing of APP Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts Spatial segregation of gamma-secretase and substrates in distinct membrane domains.The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.Plasma membrane localization of Solanum tuberosum remorin from group 1, homolog 3 is mediated by conformational changes in a novel C-terminal anchor and required for the restriction of potato virus X movement].Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle Cross-talk of membrane lipids and Alzheimer-related proteins.Metabolomic Identification in Cerebrospinal Fluid of the Effects of High Dietary Cholesterol in a Rabbit Model of Alzheimer's Disease Viable mouse gene ablations that robustly alter brain Aβ levels are rare.Secretory phospholipase A2 type III enhances alpha-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity.Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study Cellular basis of Alzheimer's disease Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing.Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein.Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.Effects of membrane lipids on the activity and processivity of purified γ-secretase Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant.N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.

P2860

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

http://www.wikidata.org/entity/Q34649008

description

2003 nî lūn-bûn

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2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

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name

Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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type

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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prefLabel

Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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Exclusively targeting beta-sec ...... the amyloid precursor protein

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PNAS.1635130100

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Proceedings of the National Academy of Sciences of the United States of America

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Exclusively targeting beta-sec ...... the amyloid precursor protein

@en

P2093

Anthony J Turner

http://www.w3.org/2001/XMLSchema#string

Colin Dingwall

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Ishrut Hussain

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Joanna M Cordy

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Lipid rafts and signal transduction

Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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11735-11740

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10.1073/PNAS.1635130100

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20

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100

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Nigel M. Hooper

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42312240

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2003-09-22T00:00:00Z

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9085597

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1035508760

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14504402

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208827

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