In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.

Item
http://www.wikidata.org/entity/Q34662307
Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alphaRole of Staphylococcus aureus Virulence Factors in Inducing Inflammation and Vascular Permeability in a Mouse Model of Bacterial EndophthalmitisChronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanismRapamycin is neuroprotective in a rat chronic hypertensive glaucoma model.Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cellsCiliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cellsDeletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosisEtanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma.Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris.Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human RetinaThe Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain.Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.Interferon-β Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor.Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model.In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.
P2860

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.

Item
http://www.wikidata.org/entity/Q34662307
description
2010 nî lūn-bûn
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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@ast
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@en
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@nl
type
label
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@ast
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@en
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@nl
prefLabel
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@ast
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@en
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
In glaucoma the upregulated tr ...... o retinal ganglion cell death.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932