about
The genetic signatures of noncoding RNAsHuman genetics and genomics a decade after the release of the draft sequence of the human genomePromiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elementsIntegrative annotation of variants from 1092 humans: application to cancer genomicsUCbase 2.0: ultraconserved sequences database (2014 update)Constraints and plasticity in genome and molecular-phenome evolutionExpression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinomaFunctional cis-regulatory genomics for systems biologyUltraconserved cDNA segments in the human transcriptome exhibit resistance to folding and implicate function in translation and alternative splicingUltraconserved elements: analyses of dosage sensitivity, motifs and boundariesUltraconservation identifies a small subset of extremely constrained developmental enhancersMethods to detect selection on noncoding DNALong non-coding RNAs and complex human diseasesUnderstanding rare and common diseases in the context of human evolutionProfile of David HausslerAbnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cellsPredicting RAD-seq Marker Numbers across the Eukaryotic Tree of LifeA large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human gliomaThe most deeply conserved noncoding sequences in plants serve similar functions to those in vertebrates despite large differences in evolutionary ratesComputational analysis and characterization of UCE-like elements (ULEs) in plant genomes29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genomeUltraconserved elements are novel phylogenomic markers that resolve placental mammal phylogeny when combined with species-tree analysisOrganizational heterogeneity of vertebrate genomesThe evolution of ultraconserved elements with different phylogenetic originsWidespread ultraconservation divergence in primates.Ultraconserved coding regions outside the homeobox of mammalian Hox genes.LTR retrotransposons reveal recent extensive inter-subspecies nonreciprocal recombination in Asian cultivated rice.Hypermutable non-synonymous sites are under stronger negative selectionDarwinian evolution in the light of genomics.Correcting the site frequency spectrum for divergence-based ascertainment.Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instabilityGC-biased evolution near human accelerated regions.The de novo sequence origin of two long non-coding genes from an inter-genic region.Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomesTUC338 promotes cell migration and invasion by targeting TIMP1 in cervical cancerEnrichment of ultraconserved elements among genomic imbalances causing mental delay and congenital anomalies.Predicting functionally important SNP classes based on negative selection.Realistic artificial DNA sequences as negative controls for computational genomics.Chromosome conformation capture uncovers potential genome-wide interactions between human conserved non-coding sequences.Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro-costo-mandibular syndrome.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Human genome ultraconserved elements are ultraselected.
@ast
Human genome ultraconserved elements are ultraselected.
@en
Human genome ultraconserved elements are ultraselected.
@nl
type
label
Human genome ultraconserved elements are ultraselected.
@ast
Human genome ultraconserved elements are ultraselected.
@en
Human genome ultraconserved elements are ultraselected.
@nl
prefLabel
Human genome ultraconserved elements are ultraselected.
@ast
Human genome ultraconserved elements are ultraselected.
@en
Human genome ultraconserved elements are ultraselected.
@nl
P2093
P2860
P356
P1433
P1476
Human genome ultraconserved elements are ultraselected.
@en
P2093
Andrew D Kern
Gill Bejerano
Ginger Fewell
Richard K Wilson
Sofie R Salama
Sol Katzman
P2860
P356
10.1126/SCIENCE.1142430
P407
P577
2007-08-01T00:00:00Z