Hot topics in aging research: protein translation and TOR signaling, 2010
about
mTOR is a key modulator of ageing and age-related diseaseRedox control of senescence and age-related diseaseMice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptomeThe African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.Tissue-specific insulin signaling in the regulation of metabolism and aging.Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-ratNaked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.Selective anti-cancer agents as anti-aging drugsMuscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation.Target of rapamycin (TOR) in nutrient signaling and growth controlTOR in the immune system.Fasting levels of hepatic p-S6 are increased in old miceResveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet.Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster.Calorie restriction does not increase short-term or long-term protein synthesis.Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion.Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice.The Ets transcription factor EHF as a regulator of cornea epithelial cell identitymTOR Inhibition: From Aging to Autism and Beyond.Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 MutantReducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans.Small nucleoli are a cellular hallmark of longevity.Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppressionA radical role for TOR in longevity.Inhibition of TORC1 signaling and increased lifespan: gained in translation?The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.Taking the rap: multiple effects of blocking mammalian target of rapamycin.Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans.Digital Gene Expression Profiling Analysis of Aged Mice under Moxibustion Treatment.
P2860
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P2860
Hot topics in aging research: protein translation and TOR signaling, 2010
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2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2011 թվականի հունվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Hot topics in aging research: protein translation and TOR signaling, 2010
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Hot topics in aging research: protein translation and TOR signaling, 2010
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Hot topics in aging research: protein translation and TOR signaling, 2010
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Hot topics in aging research: protein translation and TOR signaling, 2010
@ast
Hot topics in aging research: protein translation and TOR signaling, 2010
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Hot topics in aging research: protein translation and TOR signaling, 2010
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Hot topics in aging research: protein translation and TOR signaling, 2010
@ast
Hot topics in aging research: protein translation and TOR signaling, 2010
@en
Hot topics in aging research: protein translation and TOR signaling, 2010
@nl
P2860
P1433
P1476
Hot topics in aging research: protein translation and TOR signaling, 2010
@en
P2093
Brian K Kennedy
P2860
P304
P356
10.1111/J.1474-9726.2010.00665.X
P577
2011-01-20T00:00:00Z