High-resolution interrogation of functional elements in the noncoding genome
about
Genome engineering of stem cell organoids for disease modeling.Genome-scale CRISPR-Cas9 knockout and transcriptional activation screeningFunctional interrogation of non-coding DNA through CRISPR genome editing.CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.Capturing genomic relationships that matterRecent advances in high-throughput approaches to dissect enhancer functionCRISPR-FOCUS: A web server for designing focused CRISPR screening experiments.A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells.Three-dimensional genome architecture and emerging technologies: looping in disease.Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.Human gene essentiality.CRISPR-Cas9-mediated functional dissection of 3'-UTRs.Making the cut in the dark genome.The Future of CRISPR Applications in the Lab, the Clinic and Society.ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis.Functional assessment of human enhancer activities using whole-genome STARR-sequencing.Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1.CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control.Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering.High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.Genome Engineering for Personalized Arthritis Therapeutics.Towards CRISPR/Cas crops - bringing together genomics and genome editing.Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.CRISPR/Cas9-mediated noncoding RNA editing in human cancers.Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches.Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer-promoter contacts.The role of long noncoding RNAs in cancer: the dark matter matters.CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions.The dark side of the human genome.Deep learning in pharmacogenomics: from gene regulation to patient stratification.Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.CRISPR-based methods for high-throughput annotation of regulatory DNA.Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease.The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.Reversal of Resistance in Targeted Therapy of Metastatic Melanoma: Lessons Learned from Vemurafenib (BRAFV600E-Specific Inhibitor).CRISPR-based reagents to study the influence of the epigenome on gene expression
P2860
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P2860
High-resolution interrogation of functional elements in the noncoding genome
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
High-resolution interrogation of functional elements in the noncoding genome
@ast
High-resolution interrogation of functional elements in the noncoding genome
@en
High-resolution interrogation of functional elements in the noncoding genome
@nl
type
label
High-resolution interrogation of functional elements in the noncoding genome
@ast
High-resolution interrogation of functional elements in the noncoding genome
@en
High-resolution interrogation of functional elements in the noncoding genome
@nl
prefLabel
High-resolution interrogation of functional elements in the noncoding genome
@ast
High-resolution interrogation of functional elements in the noncoding genome
@en
High-resolution interrogation of functional elements in the noncoding genome
@nl
P2093
P2860
P356
P1433
P1476
High-resolution interrogation of functional elements in the noncoding genome
@en
P2093
Christine Cheng
Feng Zhang
Jason Wright
Julia Joung
Kaijie Zheng
Neville E Sanjana
Ophir Shalem
Pierre Fontanillas
P2860
P304
P356
10.1126/SCIENCE.AAF7613
P407
P50
P577
2016-09-01T00:00:00Z